哌拉西林钠舒巴坦钠联合左氧氟沙星治疗老年社区获得性肺炎的疗效分析  

Efficacy analysis of piperacillin sodium and sulbactam sodium combined with levofloxacin in the treatment of community-acquired pneumonia in the elderly

作　　者：张波 ZHANG Bo(Shengli Shengdong Hospital,Dongying 257000,China)

机构地区：[1]东营胜利胜东医院,257000

出　　处：《中国现代药物应用》2024年第14期106-108,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析哌拉西林钠舒巴坦钠联合左氧氟沙星治疗老年社区获得性肺炎的疗效。方法74例老年社区获得性肺炎患者,采用随机数表法将患者分为联合组和单药组,每组37例。单药组给予左氧氟沙星静脉滴注治疗,联合组在单药组基础上静脉滴注注射用哌拉西林钠舒巴坦钠治疗。对比两组患者临床疗效、治疗前后的炎性指标[C反应蛋白(CRP)、降钙素原(PCT)]水平、不良反应发生情况。结果联合组的临床总有效率为97.30%,较单药组的81.08%高,有显著差异(P<0.05)。治疗前,两组患者CRP、PCT水平比较,无显著差异(P>0.05)。治疗后,联合组患者CRP(5.21±1.00)mg/L、PCT(0.48±0.12)ng/ml较单药组的(6.46±1.24)mg/L、(0.74±0.18)ng/ml低,有显著差异(P<0.05)。联合组不良反应发生率为5.41%,较单药组的8.11%无显著差异(P>0.05)。结论在老年社区获得性肺炎的治疗中,通过采用哌拉西林钠舒巴坦钠联合左氧氟沙星的治疗方案,可获得显著疗效和理想预后,同时安全性高,值得临床推广。Objective To analyze the efficacy of piperacillin sodium and sulbactam sodium combined with levofloxacin in the treatment of community-acquired pneumonia in the elderly.Methods 74 elderly patients with community-acquired pneumonia were divided into a combination group and a single-drug group with 37 cases in each group.The single-drug group was given intravenous levofloxacin,and the combination group was given piperacillin sodium and sulbactam sodium for injection intravenously on the basis of the single-drug group.The clinical efficacy,inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT)]levels before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the combination group was 97.30%,which was significantly higher than 81.08%of the single-drug group(P<0.05).Before treatment,there were no significant differences in CRP and PCT levels between the two groups(P>0.05).After treatment,the combination group had CRP of(5.21±1.00)mg/L and PCT of(0.48±0.12)ng/ml,which were significantly lower than(6.46±1.24)mg/L and(0.74±0.18)ng/ml in the single-drug group(P<0.05).The incidence of adverse reactions in the combination group was 5.41%,and there was no significant difference compared with 8.11%in the single-drug group(P>0.05).Conclusion In the treatment of community-acquired pneumonia in the elderly,the combination of piperacillin sodium and sulbactam sodium with levofloxacin can achieve significant efficacy and ideal prognosis,and has high safety,which is worthy of clinical promotion.

关 键 词：哌拉西林钠舒巴坦钠 左氧氟沙星 老年社区获得性肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]