血清淀粉样蛋白A与冠脉病变严重程度的相关性分析  

Correlation analysis between serum amyloid protein A and the severity of coronary artery disease

作　　者：张艳昆 王琳[1] Zhang Yankun;Wang Lin(Tianjin Fourth Central Hospital,Tianjin 300140,China)

机构地区：[1]天津市第四中心医院,天津300140

出　　处：《首都食品与医药》2024年第15期42-45,共4页Capital Food Medicine

摘　　要：目的分析、研究血清淀粉样蛋白A(SAA)与冠脉病变严重程度的相关性,探讨血清淀粉样蛋白A是否可为动脉粥样硬化性心血管疾病患者的早期诊断、危险分层及判断预后提供预测价值.方法选取2023年1月-2023年12月就诊于天津市第四中心医院心血管内科三病区并行冠脉造影术(CAG)的患者345例,根据CAG结果分为冠心病组(276例)和非冠心病组(69例),冠心病亚组:根据患者病情严重程度分为稳定型心绞痛组(SAP组)、不稳定型心绞痛组(UAP组)、急性心肌梗死组(AMI组),同时分析血清淀粉样蛋白与Gensini评分的相关性,以进一步评估冠脉病变严重程度.结果冠心病组患者血清SAA明显高于非冠心病组患者,且差异具有统计学意义(P<0.05);AMI组和UAP组患者血清SAA水平明显高于SAP组,AMI组患者血清SAA水平高于UAP组,且差异均具有统计学意义(P<0.05);AMI组患者血清SAA水平与Gensini评分呈正相关,而在UAP组和SAP组两者无相关性.结论冠心病患者血清SAA水平与冠脉病变严重程度呈正相关.Objective To analyze and study the correlation between serum amyloid A(SAA)and the severity of coronary artery disease,and to explore whether serum amyloid A can provide predictive value for the early diagnosis,risk stratification and prognosis of patients with atherosclerotic cardiovascular disease.Methods 345 patients who underwent coronary angiography(CAG)in the cardiovascular department of Tianjin Fourth Central Hospital from January 2023 to December 2023 were selected.They were divided into coronary heart disease group(276 cases)and non coronary heart disease group(69 cases)based on the CAG results.The coronary heart disease subgroup was divided into stable angina group(SAP group),unstable angina group(UAP group),and acute myocardial infarction group(AMI group)according to the severity of the patient’s condition.The correlation between serum amyloid protein and Gensini score was analyzed to further evaluate the severity of coronary artery disease.Results The serum SAA of patients with coronary heart disease was significantly higher than that of patients without coronary heart disease,and the difference was statistically significant(P<0.05);the serum SAA levels in the AMI group and UAP group were significantly higher than those in the SAP group,and the serum SAA levels in the AMI group were higher than those in the UAP group,with statistical significance(P<0.05);the serum SAA levels of patients in the AMI group were positively correlated with the Gensini score,while there was no correlation between the two in the SAP group and UAP group.Conclusion The serum SAA level in patients with coronary heart disease is positively correlated with the severity of coronary artery disease.

关 键 词：血清淀粉样蛋白A 冠心病 心绞痛 急性心肌梗死 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]