脐带血炎症细胞因子及FFN、sICAM-1对新生儿宫内感染的诊断价值分析  

Analysis of diagnostic value of inflammatory cytokines,FFN,sICAM-1 in umbilical artery blood for neonatal intrauterine infection

作　　者：龙宏洋 岳修杰 胡剑翔 陈芳芳 戴小波 Long Hongyang;Yue Xiujie;Hu Jianxiang;Chen Fangfang;Dai Xiaobo(Xiangzhou District People’s Hospital of Zhuhai,Zhuhai,Guangdong 519070,China;Zhuhai High-tech Zone People’s Hospital,Zhuhai,Guangdong 519070,China)

机构地区：[1]广东省珠海市香洲区人民医院,广东珠海519070 [2]广东省珠海高新区人民医院,广东珠海519070

出　　处：《首都食品与医药》2024年第15期85-89,共5页Capital Food Medicine

基　　金：珠海市社会发展领域科技计划项目(ZH22036201210135PWC)。

摘　　要：目的探讨脐带血中白细胞介素-6(IL-6)、淀粉样蛋白A(SAA)、C反应蛋白(CRP)、降钙素原(PCT)、胎儿纤维连接蛋白原(FFN)、可溶性细胞间粘附分子-1(sICAM-1)对新生儿宫内感染的早期诊断价值.方法选择珠海市香洲区人民医院及珠海高新区人民医院2021年7月-2023年3月宫内感染的30例新生儿纳入病例组,另选择同期未发生宫内感染的新生儿30例纳入对照组.对比两组炎症细胞因子、FFN、sICAM-1及临床资料.多因素Logistic回归分析影响新生儿宫内感染的因素.受试者工作特征(ROC)曲线分析脐带血炎症细胞因子、FFN、sICAM-1对新生儿宫内感染的诊断价值.结果病例组的产妇妊娠期糖尿病比例、IL-6、SAA、CRP、PCT、FFN、sICAM-1均高于对照组(P<0.05).多因素Logistic回归分析结果显示,产妇妊娠期糖尿病、IL-6、SAA、CRP、PCT、FFN、sICAM-1均为新生儿宫内感染的独立影响因素(P<0.05).依据多因素Logistic回归分析所筛选出来的变量构建列线图风险模型,一致性指数(C-index)为0.713.ROC曲线分析显示,产妇妊娠期糖尿病、IL-6、SAA、CRP、PCT、FFN、sICAM-1单独及联合对新生儿宫内感染诊断的曲线下面积分别为0.750、0.739、0.824、0.846、0.849、0.830、0.891、0.919.结论在发生宫内感染的情况下,新生儿脐带血IL-6、SAA、CRP、PCT、FFN、sICAM-1水平均会明显上升,且是新生儿宫内感染的独立影响因素.IL-6、SAA、CRP、PCT、FFN、sICAM-1联合检测对新生儿宫内感染的诊断价值较高.Objective To investigate the early diagnostic value of interleukin-6(IL-6),amyloid A(SAA),C-reactive protein(CRP),procalcitonin(PCT),fetal fibronectin(FFN)and soluble intercellular adhesion molecule-1(sICAM-1)in umbilical artery blood for neonatal intrauterine infection.Methods 30 neonates with intrauterine infection from July 2021 to March 2023 in Xiangzhou District People’s Hospital of Zhuhai and Zhuhai High-tech Zone People’s Hospital were selected as case group,and 30 neonates without intrauterine infection during the same period were selected as control group.The inflammatory cytokines,FFN,sICAM-1 and clinical data were compared between two groups.The factors affecting neonatal intrauterine infection were analyzed by multivariate Logistic regression analysis.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of inflammatory cytokines,FFN and sICAM-1 in umbilical cord blood for neonatal intrauterine infection.Results The proportion of pregnant women with gestational diabetes mellitus,IL-6,SAA,CRP,PCT,FFN and sICAM-1 in case group were higher than those in control group(P<0.05).Multivariate Logistic regression analysis showed that,pregnant women with gestational diabetes mellitus,IL-6,SAA,CRP,PCT,FFN and sICAM-1 were independent influencing factors of neonatal intrauterine infection(P<0.05).A nomogram risk model was constructed based on the variables selected by multivariate Logistic regression analysis,and the consistency index(C-index)was 0.713.ROC curve analysis showed that,the areas under the curve of pregnant women with gestational diabetes mellitus,IL-6,SAA,CRP,PCT,FFN and SICAM-1 alone and in combination for the diagnosis of neonatal intrauterine infection were 0.750,0.739,0.824,0.846,0.849,0.830,0.891 and 0.919 respectively.Conclusion In the case of intrauterine infection,the levels of IL-6,SAA,CRP,PCT,FFN and sICAM-1 in neonatal umbilical artery blood will increase significantly,and they are independent influencing factors of neonatal intrauterine infection.The co

关 键 词：新生儿 宫内感染 脐带血 炎症细胞因子 FFN SICAM-1 诊断价值 

分 类 号：R446.1[医药卫生—诊断学]