医药用自愈性水凝胶性能和载体研究进展  

Research advances on properties and carriers of self-healing hydrogels for medical applications

作　　者：刘铭 文武龙 张炜烨 杨婧[2] 王锐[1] LIU Ming;WEN Wulong;ZHANG Weiye;YANG Jing;WANG Rui(College of Pharmacy,Heilongjiang University of Traditional Chinese Medicine,Heilongjiang Harbin 150040,China;College of Basic Medical Sciences,Heilongjiang University of Traditional Chinese Medicine,Heilongjiang Harbin 150040,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040

出　　处：《中国医院药学杂志》2024年第14期1702-1707,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金(编号:82074271);国家自然科学基金资助项目(编号:No.81603418)。

摘　　要：自愈性水凝胶是一种具有网状结构,拥有自我修复能力的一种新型材料。这种材料一方面具有本征性的自愈性,通过动态化学键实现结构断裂后重新连接。另一方面,水凝胶具有动态的自我调节性以及生物相容性,是极具潜力的药物递送载体。该文综述了基于自愈性水凝胶在药物递送领域的研究进展,探讨了自愈性水凝胶的载药系统在药剂学的应用前景和研究方向。Self-healing hydrogel is a novel type of material with reticular structure and self-healing capability.On the one hand,this material has intrinsic self-healing and realizes its self-healing property of structural fracture and reconnection through dynamic chemical bonding.On the other hand,hydrogels are dynamic,self-regulating and biocompatible,making them promising drug delivery vehicles.This review summarized the latest researches of self-healing hydrogels in the field of drug delivery.Also application prospects and research directions of drug-loading systems based upon self-healing hydrogels in pharmacy were discussed.

关 键 词：自愈性水凝胶 载体工程 靶向 给药系统 

分 类 号：R944[医药卫生—药剂学]