乳腺增生症的中西医认识及分泌型卷曲相关蛋白1(SFRP1)对发病机制的作用  

The Understanding of Traditional Chinese and Western Medicine and the Effect of SFRP1 on the Pathogenesis of Mammary Hyperplasia

作　　者：孙朝渭 刘鑫程 董禹何 杨晴竹 高晨曦 宋远航 谷丽艳[1] SUN Zhaowei;LIU Xincheng;DONG Yuhe;YANG Qingzhu;GAO Chenxi;SONG Yuanhang;GU Liyan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847

出　　处：《实用中医内科杂志》2024年第8期65-68,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金面上项目(L81874347);辽宁省教育厅科学技术研究项目(L202064);辽宁中医药大学大学生创新创业训练计划项目(S202310162017)。

摘　　要：乳腺增生病是一种由乳腺导管上皮细胞、乳腺腺泡及纤维结缔组织增生所致的疾病,该病多发于中年女性,但近年来具有年轻化的趋势,青年女性发病率逐年升高,同时乳腺增生及乳腺癌的总体病患数亦逐年提高,并有一定的癌变风险,被视为癌前病变。同时该病病因病机尚未完全明确,目前现代医学对于病因病机的研究主要分为两方面,一方面是激素,另一方面为信号通路,且激素与信号通路间存在相互调控影响的过程,病机较为复杂。因此,进一步明确乳腺增生的病因病机对该病进行积极防治十分重要。该文简述了乳腺增生病的症状,总结乳腺增生的病因病机及中西医对该病的认识,并论述分泌型卷曲相关蛋白1(Recombinant Secreted Frizzled Related Protein 1,SFRP1)对乳腺增生病的影响,对此进行综述探讨。Hyperplasia of mammary gland is a kind of disease caused by the proliferation of mammary duct epithelial cells,mammary acinar and fibrous connective tissue.This disease is mostly in middle-aged women,but in recent years,it has a trend of younger,and the incidence of young women is increasing year by year,while the overall number of breast hyperplasia and breast cancer patients is also increasing year by year.And there is a certain risk of cancer,considered precancerous lesions.At the same time,the etiology and pathogenesis of this disease have not been fully defined.At present,the research of modern medicine on etiology and pathogenesis is mainly divided into two aspects,one is hormone,the other is signal pathway,and there is a process of mutual regulation and influence between hormone and signal pathway,and the pathogenesis is relatively complicated.Therefore,it is very important to further clarify the etiology and pathogenesis of breast hyperplasia for active prevention and treatment of the disease.This article briefly describes the symptoms of hyperplasia of mammary gland,summarizes the etiology and pathogenesis of hyperplasia of mammary gland and the understanding of traditional Chinese and Western medicine on this disease,and discusses the influence of SFRP1 on hyperplasia of mammary gland.

关 键 词：乳腺增生症 分泌型卷曲相关蛋白1 病因病机 中西医结合 

分 类 号：R655.8[医药卫生—外科学]