凝血功能紊乱在脓毒症心肌损伤发病机制中作用研究进展  

Progress in the study of the role of coagulation dysfunction in the pathogenesis of sepsis-induced myocardial injury

作　　者：廖夕茗(综述) 杨国辉(审校) Liao Ximing;Yang Guohui(Guizhou Medical University/Department of Internal Medicine ICU,Affiliated Hospital of Guizhou Medical University,Guizhou Province,Guiyang 550001,China;不详)

机构地区：[1]贵州医科大学,贵阳550001 [2]贵州医科大学附属医院内科ICU

出　　处：《疑难病杂志》2024年第8期1002-1005,1010,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：贵州省科学技术基金(gzwjk2020-1-026)。

摘　　要：脓毒症是各种感染引起的宿主反应失调进而导致危及生命的器官功能障碍,全球发病率和病死率居高不下。脓毒症引起的心肌损伤(SIMI)是其最严重的并发症之一,其复杂的病理生理机制涉及过度炎性反应、氧化应激、线粒体损伤、细胞凋亡、细胞自噬及凝血功能紊乱等。其中凝血功能紊乱在发病机制中具有重要作用,早期识别和治疗凝血功能紊乱,对改善患者心脏功能和预后至关重要。文章就凝血功能紊乱在SIMI中的角色作一综述,探讨其作为治疗新靶点的可能性,为临床提供参考。Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to various infections,with persistently high global incidence and mortality rates.Myocardial injury induced by sepsis is among its most severe complications,with its complex pathophysiological mechanisms involving excessive inflammatory responses,oxidative stress,mitochondrial damage,cell apoptosis,autophagy,and coagulation dysfunction.Coagulation dysfunction plays an indispensable role,where its early recognition and treatment are crucial for improving cardiac function and prognosis in patients.The article reviews the role of coagulation dysfunction in sepsis-induced myocardial injury(SIMI),discussing its potential as a new therapeutic target,providing a reference for clinical practice.

关 键 词：脓毒症 心肌损伤 凝血功能紊乱 发病机制 

分 类 号：R542.2[医药卫生—心血管疾病] R363.21[医药卫生—内科学]