广州地区人群ALDH2多态性分布特征与心脑血管疾病的相关性研究  

Association between aldehyde dehydrogenase 2 gene polymorphism and cardiovascular and cerebrovascular diseases in Guangzhou

作　　者：闵志群 苏杭[1] Zhiqun Min;Hang Su(Central Laboratory,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou Guangdong 510260,China)

机构地区：[1]广州医科大学附属第二医院中心实验室,广东广州510260

出　　处：《中华临床实验室管理电子杂志》2024年第2期97-102,共6页Chinese Journal of Clinical Laboratory Management(Electronic Edition）

摘　　要：目的分析广州地区人群乙醛脱氢酶2(ALDH2)rs671位点多态性分布特征,以及ALDH2与心脑血管疾病的相关性。方法选取2018年1月至2021年6月到广州医科大学附属第二医院进行体检和同期诊断为心脑血管疾病的人群,回顾性分析该人群的ALDH2基因型,比较不同性别组、不同年龄组、体检人群组和不同心脑血管疾病人群组之间ALDH2多态性分布差异。结果入组人群ALDH2基因GG、GA、AA基因型频率分别为55.16%、37.80%和7.04%,符合Hardy-Weinberg遗传平衡(P>0.05)。男性和女性人群ALDH2各基因型频率相差不大,差异无统计学意义(P>0.05)。不同年龄组人群之间ALDH2各基因型分布差异无统计学意义(P>0.05)。本研究分别与北京、山东、山西地区相比,ALDH2各基因型分布差异均有统计学意义(P<0.05),但是分别与江苏、湖南、广东地区相比,ALDH2各基因型分布差异无统计学意义(P>0.05)。心脑血管疾病人群组GA、AA基因型频率分别为39.09%和9.13%,A等位基因频率为28.67%,高于体检人群组,两组比较差异均有统计学意义(均P<0.05)。对照组分别与冠心病组、脑梗死组和脑血管病组相比,ALDH2各基因型分布差异均有统计学意义(均P<0.05)。结论广州地区人群ALDH2 rs671位点的基因多态性分布特征在性别和年龄分布上均无差异,且提示携带ALDH2 A等位基因更容易患心脑血管疾病。Objective To investigate the distribution characteristics of aldehyde dehydrogenase 2(ALDH2)gene rs671 polymorphism in the population of Guangzhou,and the correlation between ALDH2 and cardiovascular and cerebrovascular diseases.Methods A retrospective analysis was conducted on the ALDH2 genotype of individuals who underwent physical examinations and were diagnosed with cardiovascular and cerebrovascular diseases at the Second Affiliated Hospital of Guangzhou Medical University from January 2018 to June 2021.The distribution differences of ALDH2 polymorphism were compared among different gender groups,different age groups,between physical examination groups and different cardiovascular and cerebrovascular disease groups.Results The frequencies of the GG,GA and AA genotypes of the ALDH2 gene in the enrolled population were 55.16%,37.80%and 7.04%,respectively,consistent with the Hardy Weinberg genetic balance(P>0.05).There was no significant difference in the frequency of ALDH2 genotypes between the male and female populations(P>0.05).There was no significant difference in the frequency of ALDH2 genotypes among different age groups(P>0.05).Compared with Beijing,Shandong and Shanxi regions,this study showed statistically significant differences in the frequency of ALDH2 genotypes(P<0.05).However,compared with Jiangsu,Hunan,and Guangdong regions,there was no statistically significant difference in the frequency of ALDH2 genotypes(P>0.05).The genotype frequencies of GA and AA in the cardiovascular and cerebrovascular disease group were 39.09%and 9.13%,respectively,and the frequency of A allele frequency was 28.67%,which was higher than that in the physical examination groups,with statistical significance(all P<0.05).The frequency differences of ALDH2 genotypes between the control group and the coronary heart disease group,cerebral infarction group,and cerebrovascular disease group were statistically significant(all P<0.05).Conclusion The distribution characteristics of gene polymorphism at the ALDH2 rs671 locus in the

关 键 词：乙醛脱氢酶2 rs671位点 基因多态性 心脑血管疾病 

分 类 号：R446[医药卫生—诊断学] R5[医药卫生—临床医学]