气相色谱-质谱联用法测定消毒湿巾中5种氯型季铵盐含量  

Determination of the contents of 5 kinds of chlorine-type quaternary ammonium salts in disinfectant wipes using gas chromatography-mass spectrometry

作　　者：刘波[1] 霍宗利[2] 张婧婧[2] LIU Bo;HUO Zong-li;ZHANG Jing-jing(Taizhou Municipal Center for Disease Control and Prevention,Taizhou Jiangsu 225300,China;Jiangsu Provincial Center for Disease Control and Prevention)

机构地区：[1]泰州市疾病预防控制中心,江苏泰州225300 [2]江苏省疾病预防控制中心

出　　处：《中国消毒学杂志》2024年第7期485-488,共4页Chinese Journal of Disinfection

基　　金：江苏省青年医学人才项目(QNRC2016543);江苏省333高层次人才培养工程([2022]3-7-023)。

摘　　要：目的建立气相色谱-质谱联用法同时检测消毒湿巾中5种氯型季铵盐含量的方法。方法采用气相色谱-质谱联用测定法,对消毒湿巾中5种氯型季铵盐含量进行检测,确定检测方法的实用性。结果在建立优化检测条件下,对消毒湿巾中氯型季铵盐在5~60μg/m L的浓度范围内线性关系良好(r>0.9993),方法检出限均为1.1~1.6μg/m L,平均回收率在86.2%~106.6%,RSD在1.4%~6.7%。结论本研究建立的气相色谱-质谱联用法具有操作简便、快速、重现性好等优点,可同时对消毒湿巾中5种氯型季铵盐含量进行测定。Objective To establish a method for simultaneous detection of 5 kinds of chlorine-type quaternary ammonium salts in disinfectant wipes using gas chromatography-mass spectrometry.Methods Gas chromatography-mass spectrometry was used to detect the contents of 5 kinds of chlorine-type quaternary ammonium salts in disinfectant wipes to determine the practicability of the detection method.Results Under the optimized detection condition,the linear relationship between chlorine-type quaternary ammonium salts in disinfectant wipes was good in the concentration range of 5 to 60μg/mL(r>0.9993),and the method detection limits were all 1.1 to 1.6μg/mL,the average recovery rate was between 86.2%and 106.6%,and the RSD was between 1.4%and 6.7%.Conclusion The gas chromatography-mass spectrometry method established in this study has the advantages of simple operation,rapidity,and good reproducibility.It can simultaneously determine the contents of 5 kinds of chlorine-type quaternary ammonium salt in disinfectant wipes.

关 键 词：消毒湿巾 消毒剂 氯型季铵盐 气相色谱-质谱法 

分 类 号：R187.2[医药卫生—流行病学]