Nanotechnology-based Detection Strategies for Hypertension Biomarkers  

作　　者：WANG Zhichao ZENG Yuan WANG Yaling CHEN Chunying 

机构地区：[1]Henan Institute of Advanced Technology,Zhengzhou University,Zhengzhou,450003,P.R.China [2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Chinese Academy of Sciences(CAS),Beijing,100190,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第4期564-576,共13页高等学校化学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22307028,82341044,22027810);the National Basic Research Program of China(Nos.2022YFA1603701,2021YFA1200900);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS 2019-I2M-5-018).

摘　　要：Hypertension significantly increases the risk of cardiovascular diseases and seriously affects people’s health.The incidence of hypertension is rising rapidly in the world and hypertension has become a significant factor influencing the global average life expectancy.The diagnosis of hypertension is generally fulfilled by measuring diastolic and systolic blood pressure,but it is insufficient to differentiate essential hypertension from secondary hypertension,so it is crucial to identifying the cause of hypertension by detecting biomarkers in plasma.In clinical practice,five plasma biomarkers are utilized for diagnosing hypertension,and the detection tasks of a large number of cases have raised increasing demands for cost-effective,efficient,speedy,and diverse methods,which makes many traditional diagnostic technologies inadequate for meeting the needs of clinical diagnosis.The nanomaterial-based detection techniques have frequently attained the qualities of quick reaction,low cost,straightforward operation,high sensitivity,and strong specificity in recent years with the advancement of nanotechnology,so they have great potential for early and rapid diagnosis.In this review,we will introduce the characteristics and drawbacks of current clinical detection methods for hypertension screening,the principles and advancements of nanotechnology-based detection methods,as well as their potentials for clinical application.

关 键 词：HYPERTENSION Biomarker Diagnosis Clinical detection Nanotechnology-based detection 

分 类 号：R544.1[医药卫生—心血管疾病]