Obstructive sleep apnea-hypopnea syndrome immunological relationship  

作　　者：Mahmoud Ali Alaa Ramadan Salim Surani 

机构地区：[1]Department of Medicine,Al-Azhar University,Damietta 11651,Egypt [2]Department of Medicine,South Valley University,Qena 83523,Egypt [3]Department of Medicine and Pharmacology,Texas A&M University,College Station,TX 77843,United States [4]Department of Anesthesiology,Mayo Clinic,Rochester,MN 55905,United States

出　　处：《World Journal of Clinical Cases》2024年第27期6011-6014,共4页世界临床病例杂志

摘　　要：Obstructive sleep apnea-hypopnea syndrome(OSAHS)is a complex disorder cha-racterized by symptoms resulting from intermittent hypoxia and hypopnea,with research indicating a crucial role of immune system dysregulation and genetic variations in its pathogenesis.A recent Zhao et al study utilizes Mendelian ran-domization analysis to explore the causal relationship between immune cell characteristics and OSAHS.The study identifies specific lymphocyte subsets as-sociated with OSAHS,providing valuable insights into the disease's pathophy-siology and potential targets for therapeutic intervention.The findings underscore the significance of genetic and immunological factors in sleep disorders,offering a fresh perspective on OSAHS's complexities.Compared to existing literature,Zhao et al's study stands out for its focus on genetic markers and specific immune responses associated with OSAHS,expanding upon previous research primarily centered on systemic inflammation.In conclusion,the study represents a signi-ficant advancement in the field,shedding light on the causal role of immune cells in OSAHS and paving the way for future research and targeted treatments.

关 键 词：Obstructive sleep apnea Mendelian randomization Lymphocyte charac-teristics IMMUNOLOGY Obstructive sleep apnea-hypopnea syndrome 

分 类 号：R392[医药卫生—免疫学] R56[医药卫生—基础医学]