猕猴脑网络组图谱:包含分区、连接和组织学的多层面全新大脑地图  

Macaque Brainnetome Atlas:A multifaceted brain map with parcellation,connection,and histology

作　　者：陆玉恒 崔玥 曹龙 董振伟 程禄祺 吴雯 王昌硕 刘新异 刘有通 张宝贵 李德莹 赵舶凯 王海艳 李开心 马亮 时维阳 李雯 马亚伟 杜宗昌 张佳琪 熊辉 罗娜 刘妍妍 侯肖逍 韩景路 孙洪吉 蔡涛 彭强 冯琳清 王骄健 George Paxinos 杨正宜 樊令仲 蒋田仔 Yuheng Lu;Yue Cui;Long Cao;Zhenwei Dong;Luqi Cheng;Wen Wu;Changshuo Wang;Xinyi Liu;Youtong Liu;Baogui Zhang;Deying Li;Bokai Zhao;Haiyan Wang;Kaixin Li;Liang Ma;Weiyang Shi;Wen Li;Yawei Ma;Zongchang Du;Jiaqi Zhang;Hui Xiong;Na Luo;Yanyan Liu;Xiaoxiao Hou;Jinglu Han;Hongji Sun;Tao Cai;Qiang Peng;Linqing Feng;Jiaojian Wang;George Paxinos;Zhengyi Yang;Lingzhong Fan;Tianzi Jiang(Brainnetome Center,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China;School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing 100049,China;University of Chinese Academy of Sciences,Beijing 100049,China;Henan Key Laboratory of Imaging and Intelligent Processing,PLA Strategic Support Force Information Engineering University,Zhengzhou 450001,China;Neuroscience Research Australia and The University of New South Wales,Sydney NSW 2031,Australia;Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,China;State Key Laboratory of Primate Biomedical Research,Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650500,China;School of Mechanical and Power Engineering,Harbin University of Science and Technology,Harbin 150080,China;School of Life and Environmental Sciences,Guilin University of Electronic Technology,Guilin 541004,China;Sino-Danish College,University of Chinese Academy of Science,Beijing 100049,China;Research Center for Augmented Intelligence,Zhejiang Lab,Hangzhou 311100,China;Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital,Yongzhou 425000,China)

机构地区：[1]Brainnetome Center,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China [2]School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing 100049,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]Henan Key Laboratory of Imaging and Intelligent Processing,PLA Strategic Support Force Information Engineering University,Zhengzhou 450001,China [5]Neuroscience Research Australia and The University of New South Wales,Sydney NSW 2031,Australia [6]Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,China [7]State Key Laboratory of Primate Biomedical Research,Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650500,China [8]School of Mechanical and Power Engineering,Harbin University of Science and Technology,Harbin 150080,China [9]School of Life and Environmental Sciences,Guilin University of Electronic Technology,Guilin 541004,China [10]Sino-Danish College,University of Chinese Academy of Science,Beijing 100049,China [11]Research Center for Augmented Intelligence,Zhejiang Lab,Hangzhou 311100,China [12]Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital,Yongzhou 425000,China

出　　处：《Science Bulletin》2024年第14期2241-2259,共19页科学通报（英文版）

基　　金：partially supported by the Science and Technology Innovation 2030-Brain Science and Brain-Inspired Intelligence Project(2021ZD0200200);the National Natural Science Foundation of China(62327805,82151307,82072099,82202253)。

摘　　要：The rhesus macaque(Macaca mulatta)is a crucial experimental animal that shares many genetic,brain organizational,and behavioral characteristics with humans.A macaque brain atlas is fundamental to biomedical and evolutionary research.However,even though connectivity is vital for understanding brain functions,a connectivity-based whole-brain atlas of the macaque has not previously been made.In this study,we created a new whole-brain map,the Macaque Brainnetome Atlas(MacBNA),based on the anatomical connectivity profiles provided by high angular and spatial resolution ex vivo diffusion MRI data.The new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and functional connections.The parcellation and the diffusion-based tractography were evaluated with invasive neuronal-tracing and Nissl-stained images.As a demonstrative application,the structural connectivity divergence between macaque and human brains was mapped using the Brainnetome atlases of those two species to uncover the genetic underpinnings of the evolutionary changes in brain structure.The resulting resource includes:(1)the thoroughly delineated Macaque Brainnetome Atlas(MacBNA),(2)regional connectivity profiles,(3)the postmortem high-resolution macaque diffusion and T2-weighted MRI dataset(Brainnetome-8),and(4)multi-contrast MRI,neuronal-tracing,and histological images collected from a single macaque.MacBNA can serve as a common reference frame for mapping multifaceted features across modalities and spatial scales and for integrative investigation and characterization of brain organization and function.Therefore,it will enrich the collaborative resource platform for nonhuman primates and facilitate translational and comparative neuroscience research.

关 键 词：Macaca mulatta Brain atlas Connectivity-based parcellation Diffusion MRI CYTOARCHITECTURE Cross-species comparison 

分 类 号：Q189[生物学—神经生物学]