Synergistic injection of the thermosensitive hydrogel and Bi-based alloy bone cement for orthopaedic repair  

作　　者：LIU SiCong LI Lei JIANG ChanYuan WANG QianYu DENG ZhongShan 

机构地区：[1]Key Laboratory of Cryogenic Science and Technology,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China [2]Department of Cleft Lip and Palate,Plastic Surgery Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144,China [3]School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China(Technological Sciences)》2024年第7期2153-2163,共11页中国科学（技术科学英文版）

基　　金：supported by the CAMS Innovation Fund for Medical Sciences (Grant No. 2021-I2 M-1–052);the Key Laboratory of Congenital Craniofacial Malformation of the Chinese Academy of Medical Sciences (Grant No. 2018PT31051);the Fund of CAMS Plastic Surgery Hospital (Grant Nos. YS202036, YS202003);the National Natural Science Foundation of China (Grant No. 31801046);the Foundation of Director of Technical Institute of Physics and Chemistry, Chinese Academy of Sciences。

摘　　要：Low-melting-point alloys have the advantages of good biocompatibility, plasticity, and near-bone mechanical strength, making them suitable as bone defect-filling materials for direct injection into defective bone sites. However, using low-melting-point alloys for orthopedic implants poses the challenge of causing thermal damage to the surrounding bone tissue during injection. In this study, a thermosensitive hydrogel is prepared and synergistically injected into the bone defect site with BiInSn. BiInSn solidifies and releases heat during injection, while the thermosensitive hydrogel absorbs heat and transforms into a gel state,encapsulating BiInSn. Therefore, the surrounding bone tissue is effectively protected from thermal damage. When BiInSn and the thermosensitive hydrogel were injected synergistically, in vitro thermal experiments revealed that the maximum temperature of the surrounding bone tissue reached 42℃. This temperature is below the 47℃ threshold, which causes permanent damage to bone tissues. In vivo experiments demonstrated that rats in the BiInSn-thermosensitive hydrogel group exhibited better recovery at the bone defect sites. These results suggest that the synergistic injection of Bi-based alloy and thermosensitive hydrogel is beneficial in reducing thermal damage to bone tissue, guiding bone tissue growth, and effectively facilitating the repair of bone defects.

关 键 词：bone defects thermosensitive hydrogel thermal damage to tissue bismuth-based alloy bone cement 

分 类 号：TQ427.26[化学工程] TG146.17[一般工业技术—材料科学与工程] R318.08[金属学及工艺—金属材料]