基于成对电解和光催化协同作用的镍催化环烷醇的芳基化反应  

Synergistic use of photocatalysis and convergent paired electrolysis for nickel-catalyzed arylation of cyclic alcohols

作　　者：刘昭然 朱萧谕 郭剑峰 马聪 左智伟 梅天胜 Zhao-Ran Liu;Xiao-Yu Zhu;Jian-Feng Guo;Cong Ma;Zhiwei Zuo;Tian-Sheng Mei(State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032,China)

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Science Bulletin》2024年第12期1866-1874,共9页科学通报（英文版）

基　　金：supported by the National Key R&D Program of China(2021YFA1500100);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0610000);the National Natural Science Foundation of China(21821002,22361142834,and 22101294);the S&TCSM of Shanghai(21ZR1476500);Natural Science Foundation of Ningbo(2023J035)。

摘　　要：The merging of transition metal catalysis with electrochemistry has become a powerful tool for organic synthesis because catalysts can govern the reactivity and selectivity.However,coupling catalysts with alkyl radical species generated by anodic oxidation remains challenging because of electrode passivation,dimerization,and overoxidation.In this study,we developed convergent paired electrolysis for the coupling of nickel catalysts with alkyl radicals derived from photoinduced ligand-to-metal charge-transfer of cyclic alcohols and iron catalysts,providing a practical method for site-specific and remote arylation of ketones.The synergistic use of photocatalysis with convergent paired electrolysis can provide alternative avenues for metal-catalyzed radical coupling reactions.

关 键 词：Organic electrochemistry Electrophotocatalysis Paired electrolysis Ni catalysis Remote arylation 

分 类 号：O621.251[理学—有机化学]