Nickel-catalyzed enantioselective reductive amination of benzylic ketones in alcohols  

作　　者：Xiuhua Wang Jianrong Steve Zhou 

机构地区：[1]State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen 518055,China

出　　处：《Science China Chemistry》2024年第8期2566-2570,共5页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (22271007);the Peking University Shenzhen Graduate School,State Key Laboratory of Chemical Oncogenomics,Shenzhen Bay Laboratory,and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs。

摘　　要：Asymmetric reductive amination directly converts ketones and amines to alkylamines, which are important motifs in medicines.We report that cationic nickel complexes of chiral diphosphines promote enantioselective reductive amination of benzylic ketones with both arylamines and benzhydrazide. Isopropanol was used as a safe and cheap source of hydrogen instead of formic acid. The reaction can be readily applied to a concise synthesis of diarylethylamines, a class of neuroactive substances.

关 键 词：transfer hydrogenation nickel catalysis chiral alkylamine reductive amination synthetic method 

分 类 号：O621.251[理学—有机化学]