Recipient functional status impacts on short and long-term intestinal transplant outcomes in United States adults  

作　　者：Sarpong Boateng Prince Ameyaw Solomon Gyabaah Yaw Adjepong Basile Njei 

机构地区：[1]Department of Medicine,Yale New Haven Health,Bridgeport Hospital,Bridgeport,CT 06610,United States [2]Department of Epidemiology and Biostatistics,University of North Texas,Fort Worth,TX 76107,United States [3]Department of Medicine,Komfo Anokye Teaching Hospital,Kumasi KS 1934,Ghana [4]Yale University School of Medicine,New Haven,CT 06520,United States [5]Section of Digestive Diseases,Yale University School of Medicine,New Haven,CT 06520,United States

出　　处：《World Journal of Transplantation》2024年第3期80-94,共15页世界移植杂志

摘　　要：BACKGROUND Recipient functional status prior to transplantation has been found to impact post-transplant outcomes in heart,liver and kidney transplants.However,information on how functional status,before and after transplant impacts post-transplant survival outcomes is lacking.AIM To investigate the impact of recipient functional status on short and long term intestinal transplant outcomes in United States adults.METHODS We conducted a retrospective cohort study on 1254 adults who underwent first-time intestinal transplantation from 2005 to 2022.The primary outcome was mortality.Using the Karnofsky Performance Status,functional impairment was categorized as severe,moderate and normal.Analyses were conducted using Kaplan-Meier curves and multivariable Cox regression.RESULTS The median age was 41 years,majority(53.4%)were women.Severe impairment was present in 28.3%of recipients.The median survival time was 906.6 days.The median survival time was 1331 and 560 days for patients with normal and severe functional impairment respectively.Recipients with severe impairment had a 56%higher risk of mortality at one year[Hazard ratio(HR)=1.56;95%CI:1.23–1.98;P<0.001]and 58%at five years(HR=1.58;95%CI:1.24–2.00;P<0.001)compared to patients with no functional impairment.Recipients with worse functional status after transplant also had poor survival outcomes.CONCLUSION Pre-and post-transplant recipient functional status is an important prognostic indicator for short-and long-term intestinal transplant outcomes.

关 键 词：Intestinal transplantation Functional status Karnofsky performance status Post-transplant outcomes Survival analysis Transplant outcome 

分 类 号：R656[医药卫生—外科学]