On the evolutionary trail of MagRs  

作　　者：Jing Zhang Yafei Chang Peng Zhang Yanqi Zhang Mengke Wei Chenyang Han Shun Wang Hui-Meng Lu Tiantian Cai Can Xie 

机构地区：[1]High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China [2]Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230036,China [3]Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui 230039,China [4]School of Life Sciences,Key Laboratory for Space Bioscience and Biotechnology,Northwestern Polytechnical University,Xi’an,Shaanxi 710072,China [5]Institute of Quantum Sensing,Zhejiang University,Hangzhou,Zhejiang 310027,China

出　　处：《Zoological Research》2024年第4期821-830,共10页动物学研究（英文）

基　　金：National Natural Science Foundation of China(31640001 and T2350005 to C.X.);Ministry of Science and Technology of China(2021ZD0140300 to C.X.);Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(Y96XC11131,E26CCG27,and E26CCD15 to C.X.,E36CWGBR24B and E36CZG14132 to T.C.)。

摘　　要：Magnetic sense,or termed magnetoreception,has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and navigation.MagRs,highly conserved A-type iron-sulfur proteins,are widely distributed across all phyla and play essential roles in both magnetoreception and iron-sulfur cluster biogenesis.However,the evolutionary origins and functional diversification of MagRs from their prokaryotic ancestor remain unclear.In this study,MagR sequences from 131 species,ranging from bacteria to humans,were selected for analysis,with 23 representative sequences covering species from prokaryotes to Mollusca,Arthropoda,Osteichthyes,Reptilia,Aves,and mammals chosen for protein expression and purification.Biochemical studies revealed a gradual increase in total iron content in MagRs during evolution.Three types of MagRs were identified,each with distinct iron and/or iron-sulfur cluster binding capacity and protein stability,indicating continuous expansion of the functional roles of MagRs during speciation and evolution.This evolutionary biochemical study provides valuable insights into how evolution shapes the physical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary trajectories of MagRs.

关 键 词：MAGNETORECEPTION Magnetoreceptor(MagR) Iron-sulfur cluster STABILITY Evolutionary biochemistry 

分 类 号：Q111[生物学—普通生物学]