基于微生物的稀土材料制备  

Microbial-driven fabrication of rare earth materials

作　　者：崔惠敬 王帆 马超 张洪杰 刘凯 Huijing Cui;Fan Wang;Chao Ma;Hongjie Zhang;Kai Liu(Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing 100084,China;State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China)

机构地区：[1]Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing 100084,China [2]State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

出　　处：《Science China Materials》2024年第8期2376-2392,共17页中国科学（材料科学）（英文版）

基　　金：supported by Beijing Natural Science Foundation(2222010);the National Key Research and Development Program of China(2022YFF0710000 and 2021YFB3502300);the National Natural Science Foundation of China(52372274,52222214,22020102003,22388101,22125701,and 22361132542);the Natural Science Foundation of Jilin Province(20210101366JC);Tsinghua University Initiative Scientific Research Program。

摘　　要：稀土元素(REEs)作为现代高科技产业发展的关键原材料,在多个前沿领域具有广泛应用.然而,由于稀土元素分布相对分散,其提取往往伴随着环境退化.此外,稀土元素的相似化学性质导致了分离过程中的高能耗和过度污染排放.为了实现稀土的绿色发展和高效资源利用,通过合成生物学技术构建了工程稀土微生物.此外,我们建立了工程稀土微生物合成平台,实现了原位合成高附加值的稀土生物材料,推动了临床转化研究和应用的进展.本文综述了稀土微生物的合理设计、高价值稀土生物材料的合成及其应用.最后,简要讨论了该领域的未来研究和发展前景.Rare earth elements(REEs)are essential raw materials vital for the advancement of modern high-tech industries.However,their extraction often leads to environmental concerns.The similar chemical properties of REEs contribute to high energy consumption and significant pollution emissions during the separation process.To address these challenges and promote sustainable development and efficient resource utilization,synthetic biology techniques have been leveraged to engineer microorganisms for rare earth fabrication.Establishing an engineered microorganism manufacture platform allows for the in-situ synthesis of high-value rare earth biomaterials.This innovation not only supports clinical translational research but also enhances applications in cutting-edge fields.This article offers a comprehensive review of the rational construction of rare earth cell factories,the synthesis of high-value rare earth biomaterials,and their diverse applications in high-tech industries.Moreover,it examines the perspectives and challenges within the domain of lanthanide materials fabrication using microbial systems.

关 键 词：稀土材料 合成生物学 微生物合成 环境退化 高科技产业发展 分离过程 发展前景 污染排放 

分 类 号：TQ133.3[化学工程—无机化工] Q939.9[生物学—微生物学]