生物材料介观结构组装及工程化的最新进展、挑战和前景  

State-of-the-art,challenges,and prospects in mesoscopic structural assembly and engineering technologies within biomaterials

作　　者：焦芸可 雷淼 唱荣航 屈雪 Yunke Jiao;Miao Lei;Ronghang Chang;Xue Qu(Key Laboratory for Ultrafine Materials of Ministry of Education,School of Material Science and Engineering,Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai 200237,China;Wenzhou Institute of Shanghai University,Wenzhou 325000,China;Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism,Shanghai 200237,China)

机构地区：[1]Key Laboratory for Ultrafine Materials of Ministry of Education,School of Material Science and Engineering,Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai 200237,China [2]Wenzhou Institute of Shanghai University,Wenzhou 325000,China [3]Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism,Shanghai 200237,China

出　　处：《Science China Materials》2024年第8期2462-2468,共7页中国科学（材料科学）（英文版）

基　　金：supported by the National Key Research and Development Program(2021YFB3800800);the National Natural Science Foundation of China(31922041,32171341,and 32301113);the 111 Project(B14018);the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee(21S31901500 and 21XD1421100);the National Postdoctoral Program for Innovative Talents(BX20230122);Shanghai Sailing Program(23YF1409700);Shanghai Postdoctoral Excellence Program(2022157);China Postdoctoral Science Foundation(2022M721136)。

摘　　要：尽管天然生物组织的组分性能有限,但其跨越多尺度的复杂有序结构赋予了其出色的功能,这一点在介观尺度尤为显著.介观结构在调控材料的物理性质和生物活性方面发挥着至关重要的作用.本文深入探讨了对组织再生修复材料进行介观结构控制的挑战,并提出了一种新型的场调控动态自组装技术.该技术以电化学沉积技术为基础,通过调控电化学参数或与其他物理场进行耦合,能够更精准地控制生物大分子组装体的介观结构,从而实现材料的高性能化.此外,本文还讨论了该技术在工程化应用上的优势.最后强调了跨学科和跨部门合作的重要性,这对于推动生物材料制造技术的产业化和商业化至关重要.总之,该技术在组织再生领域展现出了广阔的发展前景.Despite the limited properties of the components of natural biological tissues,their complex ordered structures across multiple scales confer excellent functionality,especially in terms of mesoscopic structures.Mesoscopic structures play a crucial role in modulating the physical properties and cellular activity of materials.In this article,we provide insights into the challenges of controlling mesoscopic structures in tissue repair and regeneration materials and propose the field-modulated dynamic self-assembly technique.The technique is based on electrochemical deposition(EDP)technology,which enables precise control of the mesoscopic structure of biomolecule assemblies through the modulation of electrochemical parameters or further integration with other physical fields,thus achieving high performance of the materials.In addition,the article discusses the advantages of the technology for engineering applications.The article concludes by highlighting the importance of interdisciplinary and cross-sectoral collaborations,which are essential for advancing the industrialization and commercialization of biomaterial manufacturing technologies.In conclusion,the technology shows great promise in the field of tissue regeneration.

关 键 词：电化学参数 组织再生 介观结构 跨部门合作 介观尺度 电化学沉积 物理场 工程化 

分 类 号：R318.08[医药卫生—生物医学工程]