抗菌压电材料:对细菌无选择性杀伤和不产生细菌耐药性  

Antibacterial piezoelectric materials:no selective killing of bacteria and no bacterial resistance

作　　者：冯楠 李运峰[1] Feng Nan;Li Yunfeng(Department of Oral and Maxillofacial Surgery,State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院口腔颌面外科,四川省成都市610041

出　　处：《中国组织工程研究》2025年第10期2105-2112,共8页Chinese Journal of Tissue Engineering Research

基　　金：四川省科技计划资助项目(2023NSFSC0570),项目负责人:李运峰;国家重点研发计划项目(2022YFB3804500),项目负责人之一:李运峰;成都市科技局技术创新研发项目(2022-YF05-01838-SN),项目负责人:李运峰。

摘　　要：背景:压电材料可通过催化作用产生活性氧,通过多种途径来破坏细菌,而且不会导致细菌产生耐药性。这种不依赖抗生素的抗菌方式具有明显的优势,可以对细菌进行无差别的杀伤,为今后的抗菌策略提供了一种新思路。目的:文章主要总结了有关压电材料特性与抗菌机制,并讨论了部分压电材料在抗菌领域的研究现状。方法:在Pub Med、Web of Science、中国知网和万方数据库中,以“压电材料,压电催化,活性氧,抗菌,细菌感染,抗感染,耐药性”为中文检索词,以“piezoelectric materials,piezoelectricity,piezoelectric catalysis,piezocatalysis,reactive oxygen species,ROS,bacterial infection,antibacterial strategies,anti-infection,drug resistance,drug-resistant bacteria”为英文检索词。检索时间范围重点为2013年1月至2023年12月,通过阅读文题和摘要进行初步筛选;排除中英文重复性研究及内容不相关的文献,经文献质量评价后,最后纳入68篇文献进行综述。结果与结论:(1)压电材料是一类性质稳定的环境友好型材料,其大多数具有良好的生物相容性。(2)压电材料在压电效应过程中可催化产生大量活性氧,活性氧可通过细胞外氧化和细胞内氧化,破坏细菌的细胞膜、胞内蛋白质、酶以及核酸等物质,影响细菌的结构和功能,甚至导致细菌死亡从而实现抗菌。抗菌性能与催化生成活性氧速率相关,而催化速率与材料体系、形貌及外界条件等多种因素相关。(3)压电催化产生的活性氧对细菌不具备选择性,因此表现出广谱抗菌性,且这种抗菌方式不需要依赖抗菌药物,故不会引起细菌耐药性问题。(4)结合超声波无创、可控性与穿透性强等优点,未来压电材料作为耐药菌感染的辅助或替代治疗等具有重要价值和巨大潜力。(5)目前压电材料催化效率低下的难题限制了其在抗菌领域的应用,如何提高压电催化效率成为了学者们关注�s.Repetitive studies and irrelevant articles were excluded.Finally,68 articles were included for review after literature quality evaluation.RESULTS AND CONCLUSION:(1)Piezoelectric materials are stable and environment-friendly materials,most of which show good biocompatibility.(2)Piezoelectric materials can catalyze a large amount of reactive oxygen species in the process of piezoelectric effect,combined with extracellular oxidation and intracellular oxidation,reactive oxygen species can destroy the membrane of bacteria,intracellular proteins,enzymes,and nucleic acids,disorder the structure and function,even kill the bacteria.The antibacterial performance is related to the rate of catalytic generation of reactive oxygen species,and the catalytic efficiency is related to many factors such as material system,morphology,and external conditions.(3)Reactive oxygen species producted by piezoelectric catalysis can kill bacteria without selectivity and show spectral antibacterial activity.This strategy does not rely on antibiotics and does not cause drug resistance.(4)Combined with the advantages of non-invasive,controllable,and penetrating ultrasound,piezoelectric materials will have significant value and great potential in the future as adjunctive or alternative treatments for drug-resistant bacterial infections and other fields.(5)The current challenge of low catalytic efficiency of piezoelectric materials limits its application in the field of antibacterial,how to improve the piezoelectric catalytic efficiency has become the focus of scholars’attention.

关 键 词：压电材料 纳米材料 压电效应 压电催化 活性氧 抗菌治疗 抗生素 耐药性 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R364