金属有机框架材料在骨组织工程和骨科疾病治疗中的多重应用  

Multiple applications of metal-organic framework materials in bone tissue engineering and orthopedic disease treatment

作　　者：刘云翔 张晓玉 李昊[1] 张荣 李利平 陈崇伟[1] Liu Yunxiang;Zhang Xiaoyu;Li Hao;Zhang Rong;Li Liping;Chen Chongwei(Department of Orthopedics,Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;College of Medical Imaging,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Shanxi Bethune Hospital(Tongji Shanxi Hospital,Shanxi Academy of Medical Sciences),Third Hospital of Shanxi Medical University,Taiyuan 030032,Shanxi Province,China)

机构地区：[1]山西医科大学第二医院骨科,山西省太原市030001 [2]山西医科大学医学影像学院,山西省太原市030001 [3]山西白求恩医院(山西医学科学院同济山西医院),山西医科大学第三医院,山西省太原市030032

出　　处：《中国组织工程研究》2025年第10期2151-2161,共11页Chinese Journal of Tissue Engineering Research

基　　金：山西省自然科学基金(202103021223414),项目负责人:张荣。

摘　　要：背景:金属有机框架材料因其可调节的孔隙率、较大的表面积、生物相容性良好和结构多样等独特的性质在骨组织工程和骨疾病治疗中展现出巨大的应用前景。目的:综述金属有机框架材料在骨修复、关节炎、骨感染和骨肿瘤中的研究进展、运用及优缺点,为后续研究提供参考及策略。方法:检索Web of science、Pub Med和中国知网数据库,英文检索词为“Metal-Organic Frameworks,MOFs,Orthopedics,Bone Repair,Bone Regeneration,Orthopaedic Applications,Bone Tissue Engineering,Bone Infection,Arthritis,Bone Tumor,Osteosarcoma”,中文检索词为“金属有机框架,骨科,骨修复,骨再生,骨科应用,骨组织工程,骨感染,关节炎,骨肿瘤,骨肉瘤”,检索了2015-2023年的相关文献。根据纳入与排除标准对所有文献进行初筛后,最终纳入72篇文章进行综述。结果与结论:(1)在促进骨修复过程中,金属有机框架材料中的金属离子中心能够激活相应信号通路,从而通过促进成骨基因的表达、抑制破骨细胞、促进血管生成、加速骨矿化进程4个方面促进成骨,因此,以钙、锶、钴、铜和镁离子等金属离子作为金属中心的金属有机框架材料在改善骨缺损植入物的性能方面具有很大潜力。(2)以锌/钴金属有机框架为代表的金属有机框架材料能发挥类细胞保护酶的活性,清除活性氧,促进软骨再生,与天然酶相比具有不易失活和更好的稳定性等优势。(3)锌基金属有机框架材料凭借宽带隙、光生载流子的有效分离迁移以及高稳定性的特点,在光催化领域表现出色,广泛用于细菌及肿瘤细胞的杀灭。(4)双金属金属有机框架材料由于额外金属的掺杂,导致结构性能发生优化而具有关键优势,例如锌/镁金属有机框架74具有更高的稳定性进而实现持续抗菌,钽/锆金属有机框架光吸收能力及光催化效率的增加,成为了放疗增敏剂。(5)然而,金属有机框架材料BACKGROUND:Metal-organic frameworks exhibited great potential for bone tissue engineering and bone disease treatment because of its unique merits including tunable porosity,a large specific surface area,good biocompatibility,and easy structure modification.OBJECTIVE:To review the advancements,application,strengths,and weaknesses of metal-organic framework materials in bone repair,arthritis,bone infection,and bone tumors,offering guidance and strategies for future research.METHODS:Web of Science,PubMed,and CNKI databases were searched using Chinese and English keywords“metal-organic frameworks,MOFs,orthopedics,bone repair,bone regeneration,orthopaedic applications,bone tissue engineering,bone infection,arthritis,bone tumor,osteosarcoma”for related literature published from 2015 to 2023.Following initial screening based on inclusion and exclusion criteria,72 articles were finally included for review.RESULTS AND CONCLUSION:(1)During bone repair,metal ions of metal-organic frameworks can induce bone formation by activating specific signaling pathways,which include stimulating osteogenic gene expression,inhibiting osteoclasts,encouraging blood vessel formation,and speeding up bone mineralization.Hence,metal-organic frameworks with metals like calcium,strontium,cobalt,copper,and magnesium ions show significant potential in enhancing bone implant performance.(2)Metal-organic framework materials,especially zinc/cobalt-based metal-organic frameworks,exhibit enzyme-like activities and promote cartilage regeneration by scavenging reactive oxygen species.Compared with natural enzymes,it has the advantages of not easy inactivation and better stability.(3)Zinc-based metal-organic framework materials characterized with wide band gaps,efficient separation and migration of photogenerated carriers,and high stability,the enhancement of photocatalytic activity results from enhancing the excited electron-hole widely used for the eradication of bacteria and tumor cells.(4)Bimetallic metal-organic frameworks,the doping of additiona

关 键 词：金属有机框架材料 骨组织工程 骨修复 骨感染 关节炎 骨肿瘤 MOFS 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R364