富血小板血浆及水凝胶治疗脊髓损伤  

Platelet-rich plasma and hydrogel for spinal cord injury

作　　者：赵文琪 于海驰[2] 宋艺儒 袁天阳[2] 刘钦毅[2] Zhao Wenqi;Yu Haichi;Song Yiru;Yuan Tianyang;Liu Qinyi(Bethune Second Clinical College of Medicine,Jilin University,Changchun 130012,Jilin Province,China;Second Hospital of Jilin University,Changchun 130041,Jilin Province,China)

机构地区：[1]吉林大学白求恩第二临床医学院,吉林省长春市130012 [2]吉林大学第二医院,吉林省长春市130041

出　　处：《中国组织工程研究》2025年第10期2189-2200,共12页Chinese Journal of Tissue Engineering Research

基　　金：吉林省自然科学基金项目(20210101265JC),项目负责人:于海驰。

摘　　要：背景:大量文献报道了富血小板血浆、水凝胶治疗脊髓损伤的作用及其机制,但较少文章归纳总结它们治疗脊髓损伤的策略。目的:归纳总结脊髓损伤的病理进程,富血小板血浆和水凝胶单独及联合应用修复脊髓损伤的策略。方法:应用计算机检索Pub Med和中国知网数据库建库至2024年3月之前发表的文献,中文检索词为“脊髓损伤,富血小板血浆,水凝胶”,英文检索词为“spinal cord injury,spinal cord,Platelet-rich plasma,hydrogel,angiogenesis,neuralgia,combination therapy”,按照纳入和排除标准对文献进行筛选,最终纳入128篇文献进行综述分析。结果与结论:(1)富血小板血浆的分类复杂多样,在脊髓损伤的修复性治疗应用中的效果也是各有不同,但都表现出一定的积极的效果,即具有一定的促进轴突再生、刺激血管生成、治疗神经性疼痛等作用;(2)富血小板血浆的作用主要得益于其所含的生长因子等成分;(3)水凝胶的种类也很多,在脊髓损伤的修复性治疗中主要起到填充、模拟细胞外基质、搭载药物与生物产品、作为支架搭载细胞等作用;(4)与单一的治疗方式相比,富血小板血浆和水凝胶联合治疗可更有效地促进神经再生和脊髓功能的恢复。BACKGROUND:A large number of articles have reported the effect and mechanism of platelet-rich plasma and hydrogel in the treatment of spinal cord injury,but few articles have summarized their treatment strategies for spinal cord injury.OBJECTIVE:To summarize the pathological process of spinal cord injury and the strategies of repairing spinal cord injury with platelet-rich plasma and hydrogel alone and in combination.METHODS:PubMed and CNKI databases were searched for articles published from inception to March 2024 by computer.The Chinese search terms were“spinal cord injury,platelet-rich plasma,hydrogel.”The English search terms were“spinal cord injury,spinal cord,platelet-rich plasma,hydrogel,angiogenesis,neuralgia,combination therapy.”Articles were screened according to inclusion and exclusion criteria,and 128 articles were finally included for review and analysis.RESULTS AND CONCLUSION:(1)The classification of platelet-rich plasma is complex and diverse,and the effects of platelet-rich plasma in the repair treatment of spinal cord injury are various,but they all show certain positive effects,that is,they can promote axon regeneration,stimulate angiogenesis,and treat neuropathic pain and so on.(2)The effect of platelet-rich plasma is mainly due to the growth factors contained in platelet-rich plasma.(3)There are many types of hydrogels,which mainly play the role of filling,simulating extracellular matrix,carrying drugs and biological products,and carrying cells as scaffolds in the repair treatment of spinal cord injury.(4)Compared with single therapy,combination therapy of platelet-rich plasma and hydrogel can promote nerve regeneration and spinal cord function recovery more effectively.

关 键 词：脊髓损伤 原发性损伤 继发性损伤 富血小板血浆 水凝胶 血管再生 轴突再生 神经疼痛 联合治疗 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R651.2