中药调控铁死亡途径干预睾丸生精上皮损伤的研究进展  

Intervention of traditional Chinese medicine in spermatogenic epithelium injury by regulating the ferroptosis pathway:Advances in studies

作　　者：魏锦涛(综述) 马紫阳(综述) 曹军(综述)[2] 张培海(审校)[1] WEI Jin-tao;MA Zi-yang;CAO Jun;ZHANG Pei-hai(Department of Urology and Andrology/Key Laboratory of Sichuan Province for TCM Regulation of Metabolic Diseases,The Affiliated Hospital of Chengdu University of Chinese Medicine,Chengdu,Sichuan 610075,China;Taihe Peoples Hospital,Taihe,Anhui 236600,China)

机构地区：[1]成都中医药大学附属医院泌尿外科/男科,代谢性疾病中医药调控四川省重点实验室,四川成都610075 [2]太和县人民医院,安徽太和236600

出　　处：《中华男科学杂志》2024年第5期450-455,共6页National Journal of Andrology

基　　金：成都中医药大学附属医院院基金项目(y20200019)。

摘　　要：近年来,男性不育发病率逐年上升,其中,睾丸生精上皮损伤影响睾丸的生精功能是男性不育的主要原因之一。铁死亡是一种新型细胞死亡方式。研究表明,铁死亡在睾丸细胞损伤中扮演了重要的角色。而部分中药可以通过调控睾丸生精上皮的铁死亡途径,进一步干预睾丸损伤的进展。因此,本文将重点探讨中药对睾丸细胞铁死亡途径的调控作用,并总结中药在干预睾丸生精上皮损伤方面的相关研究成果,为选择相关药物并将其应用于临床提供理论基础。The incidence of male infertility has been increasing year by year,and one of the major causes is testicular spermato-genic epithelial injury,which affects the spermatogenic function of the testis.Ferroptosis is a novel mode of cell death and plays an im-portant role in testicular cell injury.Some traditional Chinese medicines can intervene in the progression of testicular injury by regula-ting the ferroptosis pathway in testicular spermatogenic epithelia.This paper focuses on the effect of traditional Chinese drugs in regula-ting the ferroptosis pathway in testicular cells,and summarizes the advances in the studies of traditional Chinese medicines in the treat-ment of testicular spermatogenic epithelial injury,aiming to provide a theoretical basis for the selection of relevant medicines and their clinical application.

关 键 词：生精上皮 铁死亡 中药 

分 类 号：R698.2[医药卫生—泌尿科学]