去氢枞酸基苯并噻唑化合物的合成及杀菌活性  

Synthesis and Bactericidal Activity of Dehydroabietyl Benzothiazole Compounds

作　　者：曾建建 莫秀庆 黄年花 苏冬萍 韦有杰 ZENG Jianjian;MO Xiuqing;HUANG Nianhua;SU Dongping;WEI Youjie(College of Chemistry&Environment Engingeering,Baise University,Baise 533000,China)

机构地区：[1]百色学院化学与环境工程学院,广西百色533000

出　　处：《合成化学》2024年第8期743-748,共6页Chinese Journal of Synthetic Chemistry

基　　金：大学生创新创业训练计划项目(202310609154);广西教育厅2020年度广西高校中青年教师科研基础能力提升项目(2020KY19016);广西教育厅2022年度广西高校中青年教师科研基础能力提升项目(2022KY0731);广西教育厅2021年度广西高校中青年教师科研基础能力提升项目(2021KY0739)。

摘　　要：为寻找具有优良生物活性的先导化合物,进一步拓展松香的使用途径,以去氢枞酸为原料,与SOCl_(2)反应制得去氢枞酸酰氯,再与2-氨基苯并噻唑化合物反应,合成6个新型去氢枞酸基2-氨基苯并噻唑化合物(4a~4f)。化合物结构经核磁共振波谱(NMR),红外光谱(IR)和高分辨质谱(HR-MS)进行了表征。采用琼脂稀释法测试了6个化合物对小麦赤霉、番茄早疫和花生褐斑等8个病菌的杀菌活性。测试结果表明:目标化合物均对供试菌具有一定的杀菌活性,对小麦赤霉杀菌活性普遍较好,其中化合物4a和4b对小麦赤霉的杀菌活性最好,分别达到66.7%和71.8%。In order to find the lead compounds with excellent biological activity,the utilization ways of rosin were further developed.In this paper,dehydroabietyl-2-aminobenzothiazole compounds were synthesized by reacting with SOCl_(2) to dehydroabietyl-2-aminobenzothiazole compounds.The structure of the compound was confirmed by nuclear magnetic resonance spectroscopy(NMR),infrared spectroscopy(IR),and high resolution mass spectrum(HR-MS).The bactericidal activity of 6 compounds against 8 pathogens such as Gibberellus triticum,tomato early blight and peanut brown spot was tested by AGAR dilution method.All the target compounds had certain bactericidal activity against the tested bacteria,and the bactericidal activity against Gibberellum triticum was generally good.Compounds 4a and 4b showed the best bactericidal activity against Gibberellum triticum,reaching 66.7% and 71.8%,respectively.

关 键 词：去氢枞酸 噻唑 合成 抗菌活性 结构表征 

分 类 号：O621.3[理学—有机化学]