以2-硝基糖烯为中间体合成1,2-顺式-2-氨基-2-脱氧糖的研究进展  

Research Progress in The Synthesis of 1,2-Cis-2-amino-2-deoxy-glycoside Using 2-Nitroglucene as Intermediate

作　　者：张娜[1] 田飞[1] 王浩 韩立峰[1] ZHANG Na;TIAN Fei;WANG Hao;HAN Lifeng(Tianjin Key Laboratory of TCM Chemistry and Analysis,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津中医药大学,天津市中药化学与分析重点实验室,天津301617 [2]天津大学,医学工程与转化医学研究院,天津300072

出　　处：《合成化学》2024年第8期756-766,共11页Chinese Journal of Synthetic Chemistry

基　　金：现代中医药海河实验室科技项目(22HHZYSS00007)。

摘　　要：糖疫苗因具有预防肺炎、脑膜炎和婴儿败血症等疾病的作用,近年来受到广泛关注。1,2-顺式-2-氨基-2-脱氧糖苷是一种重要的糖类衍生物,许多糖缀合疫苗中含有这种化合物结构,合成该结构对糖疫苗的研发非常关键。由2-硝基糖烯合成1,2-顺式-2-氨基-2-脱氧糖,其合成条件比较温和、环保,是理想的合成前体,因此开发一种高效合成2-硝基糖烯的方法至关重要。本文综述了2-硝基糖烯的合成以及以2-硝基糖烯为中间体合成1,2-顺式-2-氨基-2-脱氧糖苷的研究进展,为糖疫苗的研发提供理论参考。The development of glyco-vaccines have received much attention in recent years because of their role in preventing diseases such as pneumonia,meningitis and infant septicaemia.1,2-Cis-2-amino-2-deoxy-glycoside is an important sugar derivative,and many sugar conjured vaccines contain this compound structure,which plays a critical role in the development of sugar vaccines.The synthesis of 1,2-cis-2-amino-2-deoxy-glycoside via 2-nitroglyals is relatively mild and environmentally friendly.It is an ideal precursor for the synthesis of 1,2-cis-2-amino-2-deoxy-glycoside,and it is necessary to develop an efficient synthesis method of 2-nitroglyals.This paper summarizes the progress in the synthesis of 2-nitroglyals and the synthesis of 1,2-cis-2-amino-2-deoxyglycosides using 2-nitroglyals as intermediates.and it is expected to provide theoretical reference for sugar vaccine development.

关 键 词：糖缀合疫苗 2-硝基糖烯 化学合成 1 2-顺式-2-氨基-2-脱氧糖苷 研究进展 

分 类 号：O629.11[理学—有机化学]