星点设计-效应面法优选复方山陈颗粒成型工艺  

Study on optimization of molding process of compound Shanchen Granules by central composite design-response surface methodology

作　　者：钟以凝 董琳琳 彭金清 陆思 秦晓雪 陈卫卫 ZHONG Yining;DONG Linlin;PENG Jinqing;LU Si;QIN Xiaoxue;CHEN Weiwei(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Guangxi Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Research Center of Guangxi Zhuang Autonomous Region Ethnic Medicine Resources and Application Engineering,Guangxi University of Chinese Medicine,Nanning 530200,China;Key Laboratory of Research and Development of Common Technology of Chinese Medicine Preparation in Guangxi Universities,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,南宁530200 [2]广西中医药大学广西壮瑶药重点实验室/壮瑶药协同创新中心/广西壮族自治区民族药资源与应用工程研究中心,南宁530200 [3]广西中医药大学广西高校中药制剂共性技术研发重点实验室,南宁530200

出　　处：《长春中医药大学学报》2024年第8期864-868,共5页Journal of Changchun University of Chinese Medicine

基　　金：广西中医药重点学建设项目(GZXK-Z-20-64)。

摘　　要：目的优选复方山陈颗粒的成型工艺。方法单因素试验筛选出稠膏的相对密度、稀释剂总用量为考察因素,以颗粒的成型率、休止角、水分和溶化性为评价指标,采用星点设计-效应面法(CCD-RSM)优选复方山陈颗粒的最佳成型工艺。结果最佳成型工艺条件为取相对密度为1.25(60℃)的稠膏与稀释剂(甘露醇:糊精=1:3)按1:3的比例混匀,制软材,过16目筛制粒,在60℃下干燥约1 h,整粒,即得。结论通过CCD-RSM优选的工艺稳定可靠,可为复方山陈颗粒的产业化生产提供参考。Objective To optimize the molding process of compound Shanchen Granules.Methods The relative density of the thick paste and the total amount of diluent were selected as the investigation factors by single factor test,and the forming rate,angle of repose,moisture and solubility of the granules were used as the evaluation indexes.The optimal molding process of compound Shanchen granules was optimized by central composite design-response surface methodology(CCD-RSM).Results The optimal molding process conditions were that the thick paste with relative density of 1.25(60℃)was mixed with diluent(mannitol:dextrin=1:3)in a ratio of 1:3 to prepare the soft material,and sieved through 16 mesh sieve to form granules,and then after drying at 60℃for about 1 hour,the whole granules were obtained.Conclusion The process optimized by CCD-RSM is stable and reliable,which can provide reference for the industrial production of compound Shanchen Granules.

关 键 词：复方山陈颗粒 星点设计-效应面法 成型工艺 

分 类 号：R283.65[医药卫生—中药学]