核酸疫苗技术平台在预防性疫苗开发中的前瞻性观点  

Prospectives of nucleic acid vaccine technology platform in preventive vaccine development

作　　者：汪萱怡 王宾 熊思东[4] 高晓明 彭育才 金侠 朱涛 英博 寸韡 姜春来 于继云 陈则 陈建军[13] 莘春林[7] Wang Xuanyi;Wang Bin;Xiong Sidong;Gao Xiaoming;Peng Yucai;Jin Xia;Zhu Tao;Ying Bo;Cun Wei;Jiang Chunlai;Yu Jiyun;Chen Ze;Chen Jianjun;Xin Chunlin(Shanghai Institute of Infectious Diseases and Biosecurity,Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China;School of Basic Medical Sciences,Fudan University,Shanghai 200032,China;Advaccine(Suzhou)Biopharmaceuticals Co.,Ltd.,Suzhou 215002,China;Institutes of Biology and Medical Sciences,Soochow University,Suzhou 215021,China;Zhuhai Lifanda Biotechnology Co.,Ltd.,Zhuhai 519000,China;Shenzhen Immuno Cure BioTech Co.,Ltd.,Shenzhen 518000,China;Tianjin CanSino Biologics Inc.,Tianjin 300457,China;Suzhou Aibo Biological Technology Co.,Ltd.,Suzhou 215123,China;Yunnan Tongning Biopharmaceutical Technology Co.,Ltd.,Kunming 650032,China;Changchun BCHT Biotechnology Co.,Changchun 130103,China;Beijing Zhendan Dingtai Health Management Co.,Ltd.,Beijing 102400,China;College of Life Sciences,Hunan Normal University,Changsha 410006,China;Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430207,China)

机构地区：[1]复旦大学生物医学研究院,上海市重大传染病和生物安全研究院,上海200032 [2]复旦大学基础医学院,上海200032 [3]艾棣维欣(苏州)生物制药有限公司,苏州215002 [4]苏州大学生物医学研究院,苏州215021 [5]珠海丽凡达生物技术有限公司,珠海519000 [6]深圳医克生物技术有限公司,深圳518000 [7]天津康希诺生物技术有限公司,天津300457 [8]苏州艾博生物科技有限公司,苏州215123 [9]云南彤宁生物制药技术有限公司,昆明650032 [10]长春百克生物科技股份公司,长春130103 [11]北京震旦鼎泰生物科技有限公司,北京102400 [12]湖南师范大学生命科学学院,长沙410006 [13]中国科学院武汉病毒研究所,武汉430207

出　　处：《中华微生物学和免疫学杂志》2024年第7期565-572,共8页Chinese Journal of Microbiology and Immunology

基　　金：中国疾病预防控制中心“中国新冠疫苗真实世界研究项目”(COVEP);上海市科技重大专项(ZD2021CY001)。

摘　　要：2023年11月,第七届全国核酸疫苗大会召开,会议深入探讨了核酸疫苗的免疫机制、安全风险及优劣势,并回顾了新型冠状病毒核酸疫苗的安全性和有效性。最终形成了会议观点,即在后疫情时代,核酸疫苗技术将在以下几个领域发挥作用:一是应对传统疫苗难以应对的病原体;二是促进传统减毒活疫苗的升级换代;三是助力开发多价与联合疫苗;四是快速响应新发及再现传染病挑战。这些观点为核酸疫苗技术的未来发展指明了方向。In November 2023,the seventh National Nucleic Acid Vaccine Conference was held to deeply discuss the immune mechanism,safety risks,advantages,and disadvantages of nucleic acid vaccines,and review the safety and effectiveness of COVID-19 vaccines developed by nucleic acid vaccine technology.Some prospectives were formed in the meeting that in the post-pandemic era,nucleic acid vaccine technology will play a role in the following areas:dealing with pathogens that are difficult to be prevented by traditional vaccines,promoting the upgrading of traditional live attenuated vaccines,contributing to the development of multivalent and combined vaccines,and rapid response to emerging and re-emerging infectious diseases.These views point out the direction for the future development of nucleic acid vaccine technology.

关 键 词：核酸 免疫保护机制 安全性 预防性 疫苗 

分 类 号：R392[医药卫生—免疫学]