手指比(2D∶4D)在男性先天性生殖发育异常中的研究进展  

Research advances of finger ratio(2D∶4D)in male congenital reproductive dysplasia

作　　者：陈祖权 丁煜 陈方[1] Chen Zuquan;Ding Yu;Chen Fang(Department of Urology,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China)

机构地区：[1]上海交通大学医学院附属儿童医院,上海市儿童医院泌尿外科,上海200062

出　　处：《中华小儿外科杂志》2024年第7期668-672,共5页Chinese Journal of Pediatric Surgery

基　　金：国家自然科学基金(81870459);上海市科学技术委员会科研计划项目(14411950403)。

摘　　要：雄激素在胎儿的睾丸、附睾和阴茎等男性生殖器官的发育过程中起着至关重要的作用,其水平异常是男性先天性生殖发育异常的主要病因之一。示指和环指长度之间的比例称为"手指比"(2D∶4D),男性手指比普遍小于女性手指比。现有研究表明手指比稳定于胎儿发育的第8~14周,与胎儿睾酮水平呈负相关,是胎儿雄激素水平的可靠生物指标,同时也是区分性别二态性的重要指标。现就目前手指比与男性先天性生殖发育异常的有关研究进展做一综述。Androgen plays an important role in the development of such male reproductive organs as testis,epididymis and penis.An abnormal regulation of androgen level during pregnancy is one of the major causes of congenital abnormal male reproductive development.Ratio between length of index/ring finger is commonly known as digit ratio(2D∶4D).It helps to distinguish sexual dimorphism.2D∶4D is generally smaller in boys than girls.Correlated negatively with androgen level,it stabilizes during gestational week 8-14.Thus it is a reliable biological indicator of androgen level during pregnancy.This review summarized the latest researches of 2D∶4D in male congenital reproductive dysplasia.

关 键 词：男性泌尿生殖系统疾病 隐睾 尿道下裂 

分 类 号：R725.9[医药卫生—儿科]