骨科基础研究的现状与展望  

The present situation and prospect of basie research in orthopedies

作　　者：杨操[1] 宋雨[1] Yang Cao;Song Yu(Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院骨科,武汉430022

出　　处：《中华实验外科杂志》2024年第7期1402-1408,共7页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(82130072、82072505);湖北省自然科学基金(2023AFB532)。

摘　　要：肌肉骨骼系统疾病日渐成为人群慢性致残的重要病因。尽管药物、康复及手术治疗可缓解疼痛、重建肢体功能进而改善患者生活质量,但尚无延缓或阻断疾病进展的早期预防和治疗手段。近年来,基础实验研究的不断深入为探讨肌肉骨骼系统疾病的发病机制及潜在干预方法奠定了坚实的理论基础,有望为早期诊断和精准治疗提供新方法。同时,现阶段基础研究多基于成熟的疾病模型和实验方法,研究模式较为传统和统一,仍不能实现高效的临床转化应用。本文将从椎间盘退变、骨关节炎、骨质疏松、干细胞及骨生物材料几个方面依次对肌肉骨骼系统疾病基础实验研究现状及未来潜在研究方向进行讨论和展望。Musculoskeletal disorders are increasingly becoming important causes of chronic disability in the population.Although the patients'quality of life could be improved by pain alleviation and limb function reconstruction through drug administration,rehabilitation,and surgical treatment,there is no early prevention and treatment method to delay or block disease progression.In recent years,the continuous deepening of basic experimental research has laid a solid theoretical foundation for exploring the pathogenesis and potential intervention methods of musculoskeletal disorders,which is expected to provide new methods for early diagnosis and precise treatment.However,due to the traditional and unified nature of current basic experimental research plans and research models,efficient clinical translation applications cannot be achieved yet.This article will discuss and prospect the present situation and potential future directions of basic experimental research on musculoskeletal disorders from several aspects,including intervertebral disc degeneration,osteoarthritis,osteoporosis,stem cells,and biomaterials.

关 键 词：肌肉骨骼系统疾病 椎间盘退变 骨关节炎 骨质疏松 干细胞 生物材料 

分 类 号：R68[医药卫生—骨科学]