跟腱病实验动物模型的研究进展  

Research progress in experimental animal models of achilles tendinopathy

作　　者：张旺 陈园园 方雪 徐剑 时玉龙 王欣[1,5] Zhang Wang;Chen Yuanyuan;Fang Xue;Xu Jian;Shi Yulong;Wang Xin(Department of Trauma and Micro-Orthopaedics,Zhongnan Hospital,Wuhan University,Wuhan 430071,China;Wuhan University Second Clinical College,Wuhan 430071,China;Department of Pathology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Division of Joint Surgery and Sports Medicine,Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Orthopedics Department,Badong Peoples Hospital,Enshi 444300,China)

机构地区：[1]武汉大学中南医院创伤与显微骨科,武汉430071 [2]武汉大学第二临床学院,武汉430071 [3]武汉大学中南医院病理科,武汉430071 [4]武汉大学中南医院关节与运动医学科,武汉430071 [5]巴东人民医院骨科,恩施444300

出　　处：《中华实验外科杂志》2024年第7期1630-1633,共4页Chinese Journal of Experimental Surgery

基　　金：湖北省骨外科学科能力建设项目(YYXKNL2022009)

摘　　要：跟腱病已成为足踝部劳损性疾病中最常见的疾病之一,目前该疾病仍无法根治。实验动物模型在了解人类跟腱病及其潜在的病理机制和治疗方法中起到了至关重要的作用。本文主要对近几年国内外跟腱病实验动物模型研究现状进行综述,探讨了几种常见造模方案的优缺点,主要从造模动物的选择、动物造模方法两个方面进行了阐述,旨在为今后研究者选择更合适、高效的跟腱病实验动物模型提供参考依据,从而更有效地治疗跟腱病。Achilles tendinopathy has become one of the most common of the strain disorders of the foot and an-kle,and the disease remains incurable.Experimental animal models play a crucial role in understanding human achil-les tendinopathy and its underlying pathological mechanisms and therapeutic approaches.In this paper,we mainly re-view the current research status of experimental animal models of achilles tendinopathy at home and abroad in recent years,discuss the advantages and disadvantages of several common modelling schemes,and at the same time elaborate on the selection of modelling animals and animal modelling methods,with the aim of providing a reference basis for re-searchers to select more appropriate and efficient experimental animal models of achilles tendinopathy in the future,so-as to treat achilles tendinopathy more effectively.

关 键 词：跟腱病 动物模型 

分 类 号：R686.1[医药卫生—骨科学] R-332[医药卫生—外科学]