高龄患者无导线起搏器植入临床疗效观察  

Clinical observation of leadless pacemaker implantation in elderly patients

作　　者：乔瀚博 方潘慧 陶元 乔增勇 邓海燕 QIAO Hanbo;FANG Panhui;TAO Yuan;QIAO Zengyong;DENG Haiyan(Department of Cardiology,Shanghai Putuo District Liqun Hospital,Shanghai,200333,China;National Standardized Training Base for General Residents;Department of Cardiology,Shanghai Fengxian District Central Hospital)

机构地区：[1]上海市普陀区利群医院心内科,上海200333 [2]上海市奉贤区中心医院全科规培基地 [3]上海市奉贤区中心医院心内科

出　　处：《临床心血管病杂志》2024年第7期570-573,共4页Journal of Clinical Cardiology

基　　金：上海市科学技术委员会基金(No:19JC1415704)。

摘　　要：目的:初步探讨高龄患者无导线起搏器植入后电学参数的稳定性,分析无导线起搏器在临床应用中的有效性及安全性。方法:本研究为回顾性、观察性研究。选取2021年8月—2023年2月于上海市奉贤区中心医院和上海市普陀区利群医院接受单、双腔无导线起搏器植入的52例年龄≥70岁患者。收集患者的基本特征以及围术期相关信息。术后随访程控参数(感知、阈值、阻抗)、超声心动图、B型利钠肽(BNP)、肌酐。收集并发症及严重不良事件发生情况。结果:52例患者均完成起搏器植入,成功率为100%。术中阈值(0.53±0.24) V/0.24 ms,感知(11.67±4.65) mV,阻抗(831.88±194.82)Ω,手术时间(39.41±19.54) min,住院时间(9.25±3.72) d。围手术期均未发生空气血栓栓塞、心脏穿孔、心包填塞等严重并发症,均未发生起搏器脱落或移位。术后1个月超声心动图显示三尖瓣功能无明显变化。术后6个月随访时,阈值(0.48±0.10) V/0.24 ms,感知(13.38±3.89) mV,阻抗(716.88±141.23)Ω,心室起搏比例为54.1%。与术中相比,术后6个月起搏感知及阈值无显著改变,阻抗则呈下降趋势(P<0.05)。结论:对于高龄患者,植入无导线起搏器术中与术后电学参数稳定,并发症发生率低,在临床应用中安全有效。Objective To preliminarily explore the stability of electrical parameters after leadless pacemaker implantation in elderly patients and evaluate the efficacy and safety of leadless pacemakers in clinical application.Methods This study was a retrospective and observational research.Fifty-two patients aged≥70 years who received single or dual chamber leadless pacemaker implantation in Shanghai Fengxian District Central Hospital and Shanghai Putuo District Liqun Hospital from August 2021 to February 2023 were selected.The basic characteristics and perioperative data were collected.The parameters of leadless pacemaker (R-wave, threshold, impedance), echocardiography, brain natriuretic peptide (BNP), and creatinine were followed up after implantation.The complications and serious adverse events were also recorded.Results Fifty-two patients completed pacemaker implantation with a success rate of 100%.The intraoperative mean ventricular pacing threshold was (0.53±0.24) V at 0.24 ms, the leadless pacemaker R-wave was (11.67±4.65) mV, impedance was (831.88±194.82)Ω, operation time was (39.41±19.54) min, and hospital stay was (9.25±3.72) d.There was no perioperative air thromboembolism, cardiac perforation, pericardial tamponade, pacemaker falling off, or shifts.The tricuspid valve function showed no significant change under echocardiography one month after implantation.The electrical parameters 6 months after implantation: mean ventricular pacing threshold was (0.48±0.10) V at 0.24 ms, leadless pacemaker R-wave was (13.38±3.89) mV, impedance was (716.88±141.23)Ω, and ventricular pacing was 54.1%.Compared with intraoperative values, there was no significant change in the leadless pacemaker R-wave or threshold, while the impedance showed a decreasing trend (P < 0.05).Conclusion For elderly patients, leadless pacemaker implantation has stable electrical parameters during and after the implantation, with the low incidence of complications.It is safe and effective in clinical applications.

关 键 词：无导线起搏器 电学参数 高龄 并发症 

分 类 号：R541.7[医药卫生—心血管疾病]