多肽口服递送的发展现状——现有策略与离子液体应用  

The Current Status of Peptide Oral Delivery--Existing Strategies and the Application of Ionic Liquids

作　　者：柳铎芳 Liu Duofang(Jiangsu Sinopep Allsino BioPharma Co.,Ltd.,Lianyungang 222000,China)

机构地区：[1]江苏诺泰澳赛诺生物制药股份有限公司,江苏连云港222000

出　　处：《广东化工》2024年第10期90-93,共4页Guangdong Chemical Industry

摘　　要：随着蛋白多肽类药物市场占有率的攀升,开发多肽口服给药可有效缓解长期、高频次的注射给药副作用多、患者依从性差等局限,前景广阔。但大多数蛋白多肽类药物口服生物利用度低,在口服制剂的研制过程中困难重重。离子液体完全由阴、阳离子构成,是一种能够提高药物口服吸收效果的新型递送材料。本文综述了多肽口服递送现状及新型功能性离子液体在多肽口服递送中的研究。首先,概述了多肽口服递送的屏障,随后介绍了多肽口服吸收策略。着重探讨了离子液体的基本性质和在生物医学领域中的潜在应用。进一步分析了这些功能性离子液体在多肽口服递送中的应用,涉及其在增强多肽的溶解度、稳定性和生物利用度等方面的作用机制和效果。最后,对当前研究中存在的挑战和未来发展方向进行了展望,以期为进一步推动新型功能性离子液体在多肽口服递送领域的研究和应用提供参考和启示。With the increasing market share of protein peptide drugs,the development of oral peptide delivery can effectively alleviate the limitations of long-term and high-frequency injection administration,such as multiple side effects and poor patient compliance,showing promising prospects.However,most protein peptide drugs have low oral bioavailability,posing significant challenges in the development of oral formulations.Ionic liquids,composed entirely of cations and anions,are a novel delivery material capable of enhancing oral drug absorption.This article reviews the current status of peptide oral delivery and the research on novel functional ionic liquids in peptide oral delivery.Firstly,the barriers of peptide oral delivery are outlined,followed by an introduction to strategies for peptide oral absorption.The basic properties of ionic liquids and their potential applications in the biomedical field are highlighted.Furthermore,the application of these functional ionic liquids in peptide oral delivery is analyzed,involving their mechanisms and effects on enhancing peptide solubility,stability,and bioavailability.Finally,the challenges and future directions in current research are discussed,aiming to provide references and insights for further promoting the research and application of novel functional ionic liquids in the field of peptide oral delivery.

关 键 词：离子液体 口服递送 司美格鲁肽 渗透促进剂 SNAC 

分 类 号：TQ[化学工程]