高分子材料在《药剂学》实验改革中的应用——以PLGA为例  

Application of Polymer Materials in the Reform of Pharmaceutical Experiments:A Case Study of PLGA

作　　者：孙琳 Sun Lin(Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,China)

机构地区：[1]遵义医科大学珠海校区,广东珠海519041

出　　处：《广东化工》2024年第13期145-147,161,共4页Guangdong Chemical Industry

基　　金：遵义医科大学珠海校区教育教学改革计划项目(XQJG2018-01-14)。

摘　　要：本文探讨了将聚乳酸-羟基乙酸共聚物(PLGA)引入药剂学实验课程的教学改革。PLGA具有良好的生物相容性和可降解性,广泛应用于药物递送系统。本研究以白藜芦醇为模型药物,通过反溶剂沉淀法制备了白藜芦醇PLGA纳米粒(Res-PLGA-NPs),并对其粒径、Zeta电位、包封率和载药量等进行了表征。实验结果表明,Res-PLGA-NPs具有粒径小、分布均匀、稳定性良好的特点,有效提高了白藜芦醇的水溶性和稳定性。通过此实验,学生能够深入理解高分子材料在药剂学领域的应用,提升实践技能和创新能力。This study investigates the integration of poly(lactic-co-glycolic acid)(PLGA)into pharmaceutical sciences experiments,focusing on its application in drug delivery systems.PLGA,with its excellent biocompatibility and degradability,is widely used in this field.Utilizing resveratrol as a model drug,resveratrol-loaded PLGA nanoparticles(Res-PLGA-NPs)were prepared via a reverse solvent precipitation method and characterized for particle size,Zeta potential,entrapment efficiency,and drug loading.The results demonstrated that Res-PLGA-NPs exhibited small particle size,uniform distribution,and good stability,effectively improving the water solubility and stability of resveratrol.This experiment allows students to gain a deeper understanding of the application of polymer materials in pharmaceutical sciences,enhancing their practical skills and fostering innovation.

关 键 词：聚乳酸-羟基乙酸共聚物(PLGA) 药剂学 实验教学 白藜芦醇 纳米粒 

分 类 号：G64[文化科学—高等教育学]