与科研融合的药剂学实验教学设计——薯蓣皂苷PLGA纳米粒的制备及表征  

Experimental Teaching Design of Pharmaceutics Integrated with Scientific Research:Preparation and Characterization of Dioscin PLGA Nanoparticles

作　　者：侯雪峰 朱磊 孙淑萍 李丽华 Hou Xuefeng;Zhu Lei;Sun Shuping;Li Lihua(School of Pharmacy,Wannan Medical College,Wuh u 241002,China)

机构地区：[1]皖南医学院药学院,安徽芜湖241002

出　　处：《广东化工》2024年第13期148-150,154,共4页Guangdong Chemical Industry

基　　金：安徽省教育厅质量工程项目(2023jyxm0655,2020zyrc158);皖南医学院药剂学校级精品课程(2022xskc03);皖南医学院质量工程项目(2020zybz02,2020jyxm20)。

摘　　要：将前沿纳米技术运用于药物制剂,设计了采用纳米沉淀法制备薯蓣皂苷PLGA纳米粒的药剂学实验课程。利用动态光散射法结合透射电镜对PLGA纳米粒的理化性质进行表征,采用超滤离心法测定薯蓣皂苷在PLGA纳米粒中的载药量和包封率。本实验可以锻炼本科生掌握运用前沿纳米技术制备新型制剂的能力,熟悉对新型纳米制剂的表征方法,进一步使学生了解新型纳米技术在药物制剂中的应用,提升学生运用新型纳米制剂技术的实践能力和科研素养。To apply advanced nanotechnology to pharmaceutical science,a pharmaceutics experimental course was designed to prepare dioscin PLGA nanoparticles by nano precipitation method.The physicochemical properties of PLGA nanoparticles were characterized by dynamic light scattering and transmission electron microscopy.The drug loading and encapsulation efficiency of dioscin in PLGA nanoparticles was determined by ultrafiltration centrifugation.This experiment can train undergraduates to master the ability to prepare novel formulations with cutting-edge nanotechnology,familiarize them with the characterization methods of novel nanoparticles,and further enable students to understand the application of new nanotechnology in pharmaceutical science,thereby enhancing their practical ability and scientific literacy in using novel nanoparticle-based formulation technology.

关 键 词：药剂学 实验教学改革 薯蓣皂苷 PLGA纳米粒 

分 类 号：TQ[化学工程]