布地奈德福莫特罗吸入对慢性阻塞性肺疾病合并肺癌稳定期患者的治疗效果  

Therapeutic effect of budesonide and formoterol inhalation on stable chronic obstructive pulmonary disease complicated by lung cancer

作　　者：侯小花[1] 李宁 袁晓梅[2] Hou Xiaohua;Li Ning;Yuan Xiaomei(Department of Respiratory and Critical Care Medicine,the Second People’s Hospital of Jiaozuo,Jiaozuo 454001,China;Ward I,Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China)

机构地区：[1]焦作市第二人民医院呼吸与危重症医学科,焦作454001 [2]新乡医学院第一附属医院呼吸与危重症医学科一病区,卫辉453100

出　　处：《中国实用医刊》2024年第12期95-98,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析布地奈德福莫特罗吸入对慢性阻塞性肺疾病合并肺癌稳定期患者的治疗效果。方法抽取2020年1月至2023年1月焦作市第二人民医院收治的120例慢性阻塞性肺疾病合并肺癌稳定期患者的临床资料进行回顾性分析。按照治疗方案将其分为参照组和观察组,每组60例。参照组予以常规方案治疗,观察组予以布地奈德福莫特罗治疗。比较两组呼吸困难改善时间、住院时间、肺功能指标[用力肺活量占预计值的百分比(FVC%)、第1秒用力呼气量占预计值的百分比(FEV1%)、最大通气量占预计值的百分比(MVV%)]水平、6 min步行距离(6MWD)、炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]水平及不良反应发生情况。结果观察组呼吸困难改善时间、住院时间短于参照组(P<0.05)。治疗后,观察组FVC%、FEV1%、MVV%水平高于参照组(P<0.05),6MWD大于参照组(P<0.05),IL-6、IL-8水平低于参照组(P<0.05)。两组不良反应总发生率比较差异未见统计学意义(P>0.05)。结论布地奈德福莫特罗吸入治疗慢性阻塞性肺疾病合并肺癌稳定期患者,可减轻炎症状态,改善肺功能,提高运动耐力,且不增加不良反应。Objective To analyze the therapeutic effect of budesonide and formoterol inhalation on stable chronic obstructive pulmonary disease complicated by lung cancer.Methods The clinical data of 120 patients with stable chronic obstructive pulmonary disease complicated by lung cancer admitted to the Second People’s Hospital of Jiaozuo from January 2020 to January 2023 were selected for retrospective analysis.According to the treatment plan,the selected patients were divided into the reference group and the observation group,with 60 cases in each group.The reference group was treated with conventional regimen,and the observation group was treated with budesonide and formoterol inhalation.The improvement time of dyspnea,hospital stay,levels of pulmonary function indexes,including percentage of predicted forced vital capacity(FVC%),percentage of predicted forced expiratory volume in 1 second(FEV1%)and percentage of predicted maximum ventilation(MVV%),6-minute walking distance(6MWD),levels of inflammatory factors,including interleukin-6(IL-6)and interleukin-8(IL-8),and incidence of adverse reactions were compared between the two groups.Results The improvement time of dyspnea and hospital stay in the observation group were shorter than those in the reference group(P<0.05).After treatment,the levels of FVC%,FEV1%and MVV%in the observation group were higher than those in the reference group(P<0.05),and the 6MWD in the observation group was greater than that in the reference group(P<0.05),however,the levels of IL-6 and IL-8 in the observation group were lower than those in the reference group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Budesonide and formoterol inhalation in the treatment of stable chronic obstructive pulmonary disease complicated by lung cancer can reduce inflammation,improve lung function,and increase exercise tolerance,without increasing adverse effects.

关 键 词：慢性阻塞性肺疾病 肺癌 布地奈德福莫特罗 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统] R734.2[医药卫生—内科学]