黄芪煎剂联合还原型谷胱甘肽治疗急性肾损伤的疗效  

Th e therapeutic effect of Huangqi decoction combined with reduced glutathione in the treatment of acute kidney injury

作　　者：张丽[1] 羊仙 张笑茹[1] Zhang Li

机构地区：[1]杭州市萧山区第一人民医院,311200

出　　处：《浙江临床医学》2024年第7期983-985,共3页Zhejiang Clinical Medical Journal

基　　金：杭州市卫生科技计划引导项目(20191231Y160)。

摘　　要：目的探讨黄芪煎剂联合还原型谷胱甘肽(GSH)治疗急性肾损伤(AKI)的疗效。方法选取2020年3月至2021年12月100例AKI患者,采用随机法分为对照组和观察组,每组各50例。对照组应用GSH治疗,观察组在对照组基础上联合中药黄芪煎剂口服。检测治疗前及治疗7 d、14 d时血清尿酸、肌酐、尿素氮、肾小球滤过率估计值(eGFR)及尿金属蛋白酶组织抑制因子-2(TIMP-2)、胰岛素样生长因子结合蛋白7(IGFBP7)水平,比较两组病情控制时间、住院时间、多尿期时间、少尿期时间、血肌酐恢复时间、不良反应及临床预后。结果治疗7d、14d,两组血清SUA、Scr、BUN、eGFR及尿TIMP-2、IGFBP7水平差异有统计学意义(P<0.05)。两组总有效率、病情控制时间、住院时间、多尿期时间、少尿期时间与Scr恢复时间比较差异有统计学意义(P<0.05)。两组不良反应率及28 d死亡率比较差异无统计学意义(P>0.05)。结论黄芪煎剂联合GSH治疗AKI能够提高临床疗效,降低血清SUA、Scr、BUN水平及尿中TIMP-2、IGFBP7水平,保护肾功能,且不增加不良反应发生率。Objective To investigate the curative effect of Huangqi Decoction combined with GSH in the treatment of acute kidney injury(AKI).Methods 100 patients with AKI were randomly divided into the control group and the observation group,with 50 cases in each group.The control group was treated with GSH,and the observation group was additionally given Chinese herbal Astragalus decoction orally on the basis of control group.Before the treatment,7 d and 14 d after treatment,the serum SUA,Scr,BUN,eGFR,and urinary TIMP-2 and IGFBP7 levels were detected,and the disease control time,hospitalization time,polyuric phase time,oliguric phase time,Scr recovery time,adverse reactions and clinical prognosis were compared between the two groups.Results On 7 d and 14 d of treatment,the differences in serum SUA,Scr,BUN,eGFR and urinary TIMP-2 and IGFBP7 levels between the two groups were statistically significant(P<0.05).There were statistically significant differences between the two groups in terms of total effective rate,disease control time,hospitalization time,polyuria period time,oliguria period time and Scr recovery time(P<0.05).There was no statistically significant difference in the comparison of adverse reaction rate and 28 d mortality rate between the two groups(P>0.05).Conclusion Huangqi decoction combined with GSH in the treatment of AKI can improve the clinical efficacy,reduce the serum levels of SUA,Scr,BUN and urinary TIMP-2 and IGFBP7,and protect renal function without increasing the incidence of adverse reactions.

关 键 词：急性肾损伤 黄芪 还原型谷胱甘肽 肾功能 

分 类 号：R692[医药卫生—泌尿科学]