温运脾肾清毒方治疗早期HIV/AIDS相关性肾损害的疗效观察  

Ef fect of Wenyunpishen Qingdu decoction on early stage of HIV/AIDS-related renal damage

作　　者：周张青 杨欢欢 崔龚珍 徐方燕 李惠莉 Zhou Zhangqing

机构地区：[1]浙江大学医学院附属杭州西溪医院,310000

出　　处：《浙江临床医学》2024年第7期986-988,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省中医药科技计划项目(2020EA092)。

摘　　要：目的探讨温运脾肾清毒方治疗脾肾阳虚型早期艾滋病病毒(HIV)/艾滋病(AIDS)相关性肾损害的疗效。方法选取2021年1月至12月59例肾阳虚型早期HIV/AIDS相关性肾损害患者,采用随机数字表法分为两组,对照组30例给予高活性抗逆转录病毒疗法(HAART)联合厄贝沙坦片治疗,观察组29例在对照组基础上联合温运脾肾清毒方治疗,两组均治疗6个月。比较两组疗效、中医症候积分、早期肾功能损害指标和安全性指标。结果观察组总有效率高于对照组(P<0.05);两组治疗后中医证候积分及β2-MG、尿蛋白、IGU、MA、尿红细胞、ACR水平比较,差异有统计学意义(P<0.05)。结论脾肾阳虚型早期HIV/AIDS相关性肾损害患者采用温运脾肾清毒方治疗具有较好的效果和安全性,具有较高的临床应用价值。Objective To explore the effect of Wenyun Pishen Qingdu Recipe on early AIDS virus(HIV)/AIDS related kidney damage of spleen kidney yang deficiency type.Methods A total of 59 patients with early HIV/AIDS related kidney damage of kidney yang deficiency type from January 2021 to December 2021 were randomly divided into two groups using a random number table method.The control group consisted of 30 patients who received highly active antiretroviral therapy(HAART)and the addition of irbesartan tablets.The observation group consisted of 29 patients who were treated on the basis of the control group by combining Wenyun Pishen Qingdu formula,and both groups received treatment for 6 months.The clinical efficacy,traditional Chinese medicine symptom scores,and early renal function damage indicators between two groups,safety indicators were compared.Results The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).After the treatment,the difference in score of Traditional Chinese Medicine Syndrome,the levels ofβ2-MG,urinary protein,IGU,MA,urinary red blood cells,and ACR between the two groups was statistically significant(P<0.05).Conclusion The application of Wen Yun Pi Shen Qing Du Formula in the treatment of early HIV/AIDS related kidney damage patients with spleen kidney yang deficiency has good efficacy,safety,and prognosis,and has high clinical application value.

关 键 词：艾滋病 早期肾损害 脾肾阳虚型 温运脾肾清毒方 安全性 

分 类 号：R259[医药卫生—中西医结合]