慢性病毒性肝炎患者血清CK-MB的临床意义  

作　　者：江军 李玉玺 曹利平[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院,310016 [2]浙江省青春医院,310020

出　　处：《浙江临床医学》2024年第7期1057-1058,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 探讨慢性病毒性肝炎患者肌酸激酶MB同工酶(CK-MB)与肝硬化的相关性。方法 收集113例慢性病毒性肝炎患者的临床资料,统计患者入院1~2 d内CK-MB活性法检测结果,将患者分为慢性病毒性肝炎组(肝炎组,44例)及肝炎后肝硬化组(肝硬化组,69例),并对肝硬化组依照Child-Pugh分级标准分为A组、B组、C组,比较各组CK-MB水平。结果 肝炎组CK-MB(14.6±4.8)U/L,肝硬化组(42.0±22.7)U/L,差异有统计学意义(P<0.01),A组、B组、C组分别为(22.2±10.6)U/L、(44.5±13.7)U/L、(63.4±24.4)U/L,三组差异有统计学意义(P<0.01),且均值逐级升高。结论 对于有慢性病毒性肝炎病史的患者,在排除肿瘤、冠心病、心肌病、心肌梗死、免疫系统及严重感染性疾病等因素后,出现CK-MB升高考虑存在肝硬化可能,并能间接反映肝硬化的严重程度。Objective To explore the correlation between creatine kinase MB isoenzyme(CK-MB)and liver cirrhosis in patients with chronic viral hepatitis.Methods After excluding relevant influencing factors,113 cases were included.All patients were divided into chronic viral hepatitis group(44 cases)and posthepatitic cirrhosis group(69 cases)according to the results of CK-MB activity method within 1-2 days after admission.The posthepatitic cirrhosis group was classified according to the child Pugh classification standard and divided into three groups,A,B and C.T-test was used to compare the results of CK-MB activaty method in hepatitis group and cirrhosis group.Then ANOVA test was used to test the results of CK-MB activaty method in groups A,B and C in post hepatitis cirrhosis group.Results The level of CK-MB activaty method in chronic viral hepatitis group was(14.6±4.8)U/L,and that in post hepatitis cirrhosis group was(42.0±22.7)U/L,the difference was statistically significant(P<0.01).In cirrhosis group,the levels of CK-MB activaty method in groups A,B and C were(22.2±10.6)U/L,(44.5±13.7)U/L and(63.4±24.4)U/L,respectively,and the difference was statistically significant among groups A,B and C(P<0.01).Conclusion For patients with a history of chronic viral hepatitis,after excluding factors such as tumor,coronary heart disease,cardiomy opathy,myocardial infarction,immune system and severe infectious diseases,the rise of CK-MB activaty method is considered to have the possibility of liver cirrhosis,and can indirectly reflect the severity of liver cirrhosis.

关 键 词：肌酸激酶同工酶 慢性病毒性肝炎 肝硬化 

分 类 号：R512.6[医药卫生—内科学]