BIS、RSO_(2)联合血清S100β、NSE水平评估急性脑损伤患儿病情严重程度及预后的价值  

Evaluation value of BIS,RSO_(2)combined with serum S100βand NSE levels for the severity and prognosis of acute brain injury in children

作　　者：李小磊 高刘炯 苏军[1] Li Xiaolei;Gao Liujiong;Su Jun(Medical Care Unit,Children’s Hospital of Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450018,China)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院内科监护室,450018

出　　处：《临床医学》2024年第6期15-18,共4页Clinical Medicine

摘　　要：目的探讨脑电双频指数(BIS)、局部脑氧饱和度(RSO_(2))联合血清中枢神经特异性蛋白(S100β)、神经元特异性烯醇化酶(NSE)水平评估急性脑损伤(ABI)患儿病情严重程度及预后的价值。方法选择2019年4月至2023年2月在郑州大学附属儿童医院内科监护室治疗的82例ABI患儿作为研究组,选取同期收治的肺炎患儿42例作为对照组。根据格拉斯哥昏迷量表评估研究组患儿脑损伤严重程度,分为重度组(n=16)、中度组(n=36)与轻度组(n=30);根据格拉斯哥预后量表评估研究组患儿治疗3个月后预后情况,分为预后良好组(n=52)与预后不良组(n=30)。比较对照组与研究组BIS、RSO_(2)及血清S100β、NSE水平,比较研究组中不同程度脑损伤患儿BIS、RSO_(2)及血清S100β、NSE水平,比较研究组中不同预后患儿BIS、RSO_(2)及血清S100β、NSE水平,分析上述指标对ABI患儿不良预后的预测价值。结果研究组BIS、RSO_(2)低于对照组,血清S100β及NSE水平高于对照组,差异有统计学意义(P<0.05);研究组随着脑损伤严重程度逐渐增加,BIS、RSO_(2)水平逐渐降低,血清S100β、NSE水平逐渐升高(P<0.05);研究组中预后不良组BIS、RSO_(2)水平低于预后良好组,血清S100β及NSE水平高于预后良好组(P<0.05);ROC曲线结果显示,BIS、RSO_(2)、S100β、NSE单独及联合应用评估预后的AUC分别为0.886、0.911、0.811、0.890及0.954。结论ABI患儿的BIS、RSO_(2)水平显著降低,血清S100β、NSE水平显著升高,且与病情严重程度及预后相关,联合检测对ABI患儿不良预后的预测价值较高。Objective To invesitigate the evaluation value of bifrequency index(BIS),local oxygen saturation(RSO_(2))combined with serum central nerve specific protein(S100β),neuron specific enolase(NSE)levels on the severity and prognosis of acute brain injury(ABI)in children.Methods Eighty⁃two children with ABI who underwent acute treatment at PICU in Children’s Hospital of Zhengzhou University from April 2019 to February 2023 were selected as the study group,while 42 children with pneumonia in our department were selected as the control group during the same period.According to the Glasgow Coma Scale,the degree of brain injury in the study group was evaluated,and they were divided into a severe group(n=16),a moderate group(n=36),and a mild group(n=30).According to the Glasgow Prognosis Scale,the prognosis of the study group after 3 months of treatment was evaluated,and they were divided into a good prognosis group(n=52)and a poor prognosis group(n=30).The levels of BIS,RSO_(2),serum S100β,and NSE between the control group and the study group were compared;the levels of BIS,RSO_(2),serum S100βand NSE in children with different degrees of brain injury in the study group were compared;the levels of BIS,RSO_(2),serum S100βand NSE in children with different prognosis in the study group were compared.The predictive value of the above indicators for poor prognosis in children with ABI was analyzed.Results The levels of BIS and RSO_(2) of the study group were lower than those of the control group,and the levels of serum S100βand NSE levels were higher than those of the control group(P<0.05).As the degree of brain injury gradually increased in the study group,the levels of BIS and RSO_(2) gradually decreased,and the levels of serum S100βand NSE gradually increased(P<0.05).The levels of BIS and RSO_(2) of the poor prognosis group in the study group were lower than those of the good prognosis group,and the serum levels of S100βand NSE were higher than those of the good prognosis group(P<0.05).The ROC curve results showed

关 键 词：急性脑损伤 脑电双频指数 局部脑氧饱和度 中枢神经特异性蛋白 神经元特异性烯醇化酶 病情程度 预后 

分 类 号：R726.5[医药卫生—儿科]