出 处:《临床医学》2024年第7期85-88,共4页Clinical Medicine
摘 要:目的比较α-硫辛酸分别联合依帕司他与胰激肽原酶治疗糖尿病并发周围神经病变的疗效。方法选取2021年1月至2022年12月洛阳市中心医院收治的132例糖尿病并发周围神经病变患者为研究对象,按照随机数字表法分为观察组与对照组,每组66例。观察组予以α-硫辛酸联合依帕司他治疗,对照组予以α-硫辛酸联合胰激肽原酶治疗。评估两组临床疗效、神经传导速度[正中神经、腓总神经的运动神经传导速度(MCV)、感觉神经传导速度(SCV)]、氧化应激指标[丙二醛(MDA)、8-羟化脱氧鸟苷(8-OHdG)、超氧化物歧化酶(SOD)]水平、炎症因子[胱抑素C(Cys C)、白细胞介素-17(IL-17)、缺氧诱导因子-1α(HIF-1α)]水平、治疗安全性。结果观察组治疗总有效率为92.42%(61/66),对照组为77.27%(51/66),两组比较差异有统计学意义(P<0.05)。观察组正中神经、腓总神经的SCV、MCV均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组MDA、8-OHdG水平低于对照组,SOD水平高于对照组,Cys C、IL-17、HIF-1α水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异未见统计学意义(P>0.05)。结论α-硫辛酸联合依帕司他治疗糖尿病并发周围神经病变的疗效优于α-硫辛酸联合胰激肽原酶的疗效,且可提高患者的神经传导速度,降低氧化应激反应水平,抑制炎症反应发生,且治疗安全性良好。Objective To compare the efficacy ofα-lipoic acid combined with epalrestat and pancreatikcininogenasee respectively on diabetes mellitus complicated by peripheral neuropathy.Methods One hundred and thirty-two cases of diabetes mellitus complicated by peripheral neuropathy admitted to the Central Hospital of Luoyang from January 2021 to December 2022 were selected and divided into control group and observation group,with 66 cases in each group.The observation group was treated withα-lipoic acid combined with epalrestat,and the control group was treated withα-lipoic acid combined with pancreatic kininogenase.The clinical efficacy,nerve conduction velocity[motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV)of median nerve and common peroneal nerve],oxidative stress index[malondialdehyde(MDA),8-hydroxyldeoxyguanosine(8-OHdG),superoxide dismutase(SOD)]levels,inflammatory factor[cystatin C(Cys C),interleukin-17(IL-17),hypoxiainducing factor-lα(HIF-lα)J levels and treatment safety were evaluated in the two groups.Results The total effective rate in the observation group was 92.42%(61/66),which was higher than that in the control group[77.27%(51/66)](P<0.05).The SCV and MCV of median nerve and common peroneal nerve in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of malondialdehyde(MDA)and 8-hydroxydeoxyguanosine(8-OHdG)in the observation group were lower than those in the control group,and the levels of superoxide dismutase(SOD)was higher than that in the control group(P<0.05).After treatment,the levels of serum cystatin C(Cys C),interleukin-17(IL-17)and hypoxia-inducible factor-lα((HIF-1α)were lower in the observation group than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions TThe efficacy ofα-lipoic acid combined with epalrestat in the treatment of diabetes mellitus complicated by peripheral neuropathy is better than that ofα-lip
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