基于微结构复制精度的COC微流控芯片注塑工艺优化  

Optimization of Injection Molding Process of COC Microfluidic Chip Based on Microstructure Repeatability

作　　者：谢于锰 徐林龙 张亚军[2] 金志明[2] XIE Yumeng;XU Linlong;ZHANG Yajun;JIN Zhiming(LK Injection Molding Machine Co.,Ltd.,Zhongshan,Guangdong 528415,China;College of Mechanical and Electrical Engineering,Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]广东力劲塑机智造股份有限公司,广东中山528415 [2]北京化工大学,机电工程学院,北京100029

出　　处：《塑料》2024年第4期102-104,115,共4页Plastics

摘　　要：微流控芯片在生化分析、医疗检测、环境监测等众多领域均得到了广泛应用,聚合物基微流控芯片材料具有较好的生物兼容性、相对较低的价格,注塑成型是其重要的量产方式之一。因此,设计了一种用于流体混合的聚合物基注射成型微流控芯片。基于正交实验和极差分析,探究了熔体温度、冷却时间、注射速度对芯片收缩率的影响,并且,通过优化工艺参数提高了微流控芯片的复制精度,降低了其收缩变形量。最佳工艺参数组合为熔体温度为250℃、注射速度为120 mm/s、冷却时间为10 s,在该条件下,微流控芯片主流道宽度为360.876μm,主流道深度为66.15μm,混合微通道鱼骨部分相对微通道顶部深度为106.92μm,微通道底部的粗糙度为0.19μm。Microfluidics chips were widely used in biochemical analysis,medical detection,environmental monitoring and many other fields.Polymer based Microfluidics chip materials had advantages in biological compatibility,price and other aspects.Injection molding was one of its important mass production methods.In this paper,a polymer based injection molded Microfluidics chip for fluid mixing was designed.Based on orthogonal experiments and range analysis,the influence of melt temperature,cooling time,and injection speed on the chip shrinkage was explored,and chemical conditions were optimized to improve the replication precision of Microfluidics chips and reduce their shrinkage deformation.Under the optimized process conditions(the melt temperature parameter was 250℃,the injection speed was 120 mm/s,and the cooling time was 10 s),the width of the main channel of the Microfluidics chip was 360.876μm.The depth of the main channel was 66.15μm.The depth of the mixed microchannel fishbone relative to the top of the microchannel was 106.92μm.The roughness value at the bottom of the microchannel was 0.19μm.

关 键 词：微流控芯片 注塑加工 COC 正交实验 优化 

分 类 号：TQ320.66[化学工程—合成树脂塑料工业]