葡萄糖-6-磷酸脱氢酶在病毒感染中的作用  

Role of Glucose-6-phosphate Dehydrogenase in Viral Infection

作　　者：陈冬雪 李云龙[1] 魏大巧[1] 黄芬[1] CHEN Dong-Xue;LI Yun-Long;WEI Da-Qiao;HUANG Fen(Medical School,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学基础医学院,昆明650500

出　　处：《生物化学与生物物理进展》2024年第8期1788-1796,共9页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(82260396);云南省基础研究重点项目(202401AS070057)资助。

摘　　要：葡萄糖-6-磷酸脱氢酶(glucose-6-phosphate dehydrogenase,G6PD)是磷酸戊糖途径的第一个限速酶,不仅能维持细胞内还原型辅酶Ⅱ(nicotinamide adenine dinucleotide phosphate,NADPH)和还原型谷胱甘肽(reduced glutathione,GSH)的平衡,而且在维持细胞内氧化还原平衡中也起着重要作用。研究表明,G6PD活性的降低可导致细胞内的氧化还原平衡被打破,趋向于氧化态,这不仅会导致细胞生长和信号传递的失调,还会使机体对病毒更易感。然而,目前关于G6PD的变化对病毒感染易感性的影响还没有系统的文献报道。本文将对病毒感染与G6PD之间的关系进行综述。Glucose-6-phosphate dehydrogenase(G6PD)is the first rate-limiting enzyme of the pentose phosphate pathway,which regulates the production of nicotinamide adenine dinucleotide phosphate(NADPH)in cells,and plays an important role in redox reactions.In addition,NADPH is necessary for biosynthesis reactions and is an essential hydrogen donor in the biosynthesis of cholesterol,fatty acids,and sex hormones.NADPH also plays an important role in maintaining intracellular redox homeostasis,converting intracellular oxidized glutathione into reduced glutathione(GSH),which is the main intracellular antioxidant.Therefore,G6PD plays an important role in maintaining intracellular redox homeostasis.Studies have shown that the decrease in G6PD activity can lead to a breakdown of the redox balance in the cells and tends to the oxidation state,which not only leads to dysregulation of cell growth and signaling,but also makes the host more susceptible to viruses.Previous studies have focused on the molecular characteristics of G6PD,anemia caused by G6PD deficiency,and the relationship between malignant tumors and G6PD.In recent years,more attentions have been paid to the importance of G6PD at the cellular level,development,and disease progression.To explore the effects of G6PD on viral life cycle,the relationship between G6PD and viral infections,including the clinical symptoms and virushost interactions of hepatitis B virus(HBV),human papilloma virus(HPV),hepatitis E virus(HEV),influenza virus and dengue fever virus(DENV)will be reviewed,which will benefit the antiviral drugs development.Many studies had proved that patients with deficient G6PD are more susceptible to HBV infection.It has been reported that HBV infection activates the glycolytic pathway,promotes pentose phosphate pathway,and accelerates citric acid cycle to enhance nucleotide and fat biosynthesis,thereby promoting viral replication.During HPV infection,miR-206 up-regulates the expression of G6PD to facilitate viral replication.Thus,G6PD may be a new target for anti-c

关 键 词：葡萄糖-6-磷酸脱氢酶 病毒感染 氧化还原 还原型辅酶Ⅱ 

分 类 号：R373[医药卫生—病原生物学]