Effects of Polygala fallax Hemsl Water Extract on a Mouse Model of Gastric Motility Disorders  

作　　者：Liangyin ZHU Xiaofeng HAO Liuqi HUANG Zongyuan CHEN Wenfeng CHEN Liu YANG Bingchen HUANG Liyuan LI Aipeng LI Suoyi HUANG Xiuzhen SU 

机构地区：[1]School of Clinical Medicine,Youjiang Medical University for Nationalities,Baise 533000,China [2]Key Laboratory of Guangxi Universities on National Medicine in Youjiang River,Youjiang Medical University for Nationalities,Baise 533000,China [3]School of Pharmacy,Youjiang Medical University for Nationalities,Baise 533000,China [4]Institute of Life Sciences,Youjiang Medical University for Nationalities,Baise 533000,China

出　　处：《Medicinal Plant》2024年第4期101-106,共6页药用植物：英文版

基　　金：2022 National College Student Innovation and Entrepreneurship Training Program(202210599004).

摘　　要：[Objectives]To explore the effects of Polygona fallax Hemsl water extract on gastrointestinal motility in normal mice and gastric motility disorder model mice and approximate mechanism.[Methods]Using normal mice and mice with gastric motility disorders(modeled with atropine),the effects of different mass concentration groups of P.fallax Hemsl water extract(0.125,0.250,0.500 g/mL)and domperidone groups on gastric residual rate,small intestine propulsion rate,serum motilin(MLT),vasoactive intestinal peptide(VIP),and tissue morphology were studied.[Results]There was a highly significant difference(P<0.01)in the small intestine propulsion rate of liquid in normal mice among the different concentration groups of P.fallax Hemsl water extract compared to the blank group.The small intestine propulsion rate and gastric residue rate of semi-solid paste were statistically significant compared to the blank group(P<0.05).Among them,there was a highly significant difference between the high concentration group(67.75%±7.65%,46.5%±10.62%)and the medium concentration group(60.90%±5.87%,59.27%±7.82%)(P<0.01).There was statistical significance in normal mouse serum MLT content in the high concentration group(P<0.05).There was no effect on serum VIP levels in normal mice;no effect on the morphology of stomach and intestinal tissues of normal mice.The small intestine propulsion rate and gastric residue rate of liquid and semi-solid paste in mice with gastric motility disorders were statistically significant compared to the atropine group,with extremely significant differences(P<0.01).[Conclusions]P.fallax Hemsl water extract has a promoting effect on gastrointestinal motility.One of the specific mechanisms by which P.fallax Hemsl promotes gastrointestinal motility in normal mice may be related to the content of MLT in mouse serum.The mechanism of action in atropine induced gastric paresis mice may be related to the reactivation of M receptors,and the action mechanism of P.fallax Hemsl does not change the original histological bas

关 键 词：Polygala fallax Hemsl Gastric motility Mouse model Gastric emptying Gastric paresis MOTILIN Vasoactive intestinal peptide 

分 类 号：R285[医药卫生—中药学]