核心岩藻糖修饰与疾病相关性研究进展  

Research progresses on the correlation between core fucosylation of proteins and diseases

作　　者：闵瑶 张平博 周阳 赵新元[1] 陈萃英 应万涛[1] MIN Yao;ZHANG Pingbo;ZHOU Yang;ZHAO Xinyuan;CHEN Cuiying;YING Wantao(State Key Laboratory of Medical Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences(Beijing),Beijing Institute of Lifeomics,Beijing 102206,China;不详)

机构地区：[1]医学蛋白质组全国重点实验室北京蛋白质组研究中心国家蛋白质科学中心(北京)军事科学院军事医学研究院生命组学研究所,北京102206 [2]先思达(南京)生物科技有限公司,江苏南京211800

出　　处：《中国病毒病杂志》2024年第3期239-247,共9页Chinese Journal of Viral Diseases

基　　金：国家自然科学基金青年科学基金项目(32001048)。

摘　　要：糖基化是生物体内功能最多样的一种翻译后修饰,核心岩藻糖(core fucose,CF)为N-聚糖的一种常见糖型,受α-1,6岩藻糖基转移酶催化调控。近年来研究表明,CF修饰在肿瘤等疾病的发生与进展中发挥重要作用。糖蛋白丰度较低、糖链的微观不均一性以及质谱等检测技术的限制,给CF修饰蛋白质的发现及应用研究带来了极大的挑战。本文主要介绍蛋白质CF修饰的生物合成、调控机制以及参与调控的生理病理过程,期望为CF修饰蛋白质的发现及临床应用提供新思路。Glycosylation is one of the post-translational modifications with the most diverse functions in living organisms.Core fucose(CF)is a common glycoform of N-glycans which is catalytically regulated byα-1,6fucosyltransferase.Researches in recent years have shown that CF plays an important role in the development and progression of tumors and other diseases.Challenges from low glycoprotein abundance,microheterogeneity of glycan chains,and detection techniques such as mass spectrometry have posed great challenges to the discovery of CF-modified proteins and application studies.This review will introduce the biosynthesis and regulatory mechanism of protein CF modification,and its roles in the regulation of physiopathological processes,with the expectation to provide insights for the discovery and clinical application of CF-modified proteins.

关 键 词：核心岩藻糖 α-1 6岩藻糖基转移酶(FUT8) 生物标志物 肿瘤 

分 类 号：R34[医药卫生—基础医学]