五味痛风丸提取及制备工艺研究  

Study on the Extraction and Preparation Technology of Wuwei Tongfeng Pill

作　　者：姚永秀[1,2] 章斌 梁林辉[1,2] Yao Yongxiu;Zhang Bin;Liang Linhui(Yaan Polytechnic College,Yaan 625000,China;Ya’an Application and Development of Food and Drug Engineering Technology Research Center,Yaan 625000,China)

机构地区：[1]雅安职业技术学院,四川雅安625000 [2]雅安市食品药品应用开发工程技术研究中心,四川雅安625000

出　　处：《广东化工》2024年第14期49-52,共4页Guangdong Chemical Industry

基　　金：2021年第三批省级科技计划项目(22ZYZF0003);雅安职业技术学院高层次人才中药制剂研究工作室科研项目(Yzygcky202219)。

摘　　要：目的:将五味痛风汤开发为五味痛风丸。方法:以加水倍数、煎煮时间、煎煮次数为考察因素,以秦皮乙素转移率和干浸膏率为评价指标,采用正交设计优化五味痛风丸的提取工艺,并进行丸剂成型工艺研究。结果:最佳提取工艺为加12倍水、煎煮1.5小时、煎煮3次;最佳成型工艺为提取液减压浓缩至相对密度为1.30~1.40,吴茱萸和红曲粉碎过100目筛,混匀后制丸,70℃干燥24小时。结论:该提取、制备工艺稳定可行。Objective:To develop Wuwei Tongfeng decoction into Wuwei Tongfeng pill.Methods:An orthogonal design was adopted,with the amount of water added,decoction time,and decoction times as factors,and the transfer rate of aesculetin and dry extract rate as evaluation indicators,to optimize the extraction process of Wuwei Tongfeng pill.Research on the pill preparation process was also conducted.Results:The best extraction process was to add 12 times water,extract for 1.5 hours,and extract 3 times;the optimal molding process was to concentrate the extract under reduced pressure to a relative density of 1.30~1.40,crush Euodiae Fructus and Fermentum Rubrum through a 100-mesh sieve,and mix after homogenization,make pills and dry at 70℃for 24 hours.Conclusion:The extraction and preparation process are stable and feasible.

关 键 词：五味痛风丸 秦皮乙素 提取工艺 制备工艺 正交试验 

分 类 号：R283.6[医药卫生—中药学]