补阳还五汤化学成分、药理作用研究进展及质量标志物(Q-Marker)预测  

Chemical constituents and pharmacological effects of Buyang Huanwu Decoction and predictive analysis of quality markers

作　　者：李海英[1,3] 贺鹏 李文姣 杨磊 唐林[1] 胡超[1] 邓凯文 潘雪[2,3,4,5] 贺福元 LI Haiying;HE Peng;LI Wenjiao;YANG Lei;TANG Lin;HU Chao;DENG Kaiwen;PAN Xue;HE Fuyuan(The First Affinity Hospital,Hunan University of Traditional Chinese Medicine,Changsha 410007,China;College of Pharmacy,Hunan University of Traditional Chinese Medicine,Changsha 410208,China;Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine of Hunan Province,Changsha 410208,China;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medicine,Hunan University of Traditional Chinese Medicine,Changsha 410208,China;Property and Pharmacodaynamic Key Laboratory of Traditional Chinese Medicine,National Administration of Traditional Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学药学院,湖南长沙410208 [3]中药成药性与制剂制备湖南省重点实验室,湖南长沙410208 [4]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208 [5]中药药性与药效国家中医药管理局重点实验室,湖南长沙410208

出　　处：《中草药》2024年第13期4575-4587,共13页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82274215);湖南省科技创新计划项目(2022SK2014);湖南省自然科学基金项目(2022JJ30453,2024JJ6362,2024JJ8151);湖南省卫生健康委一般项目(D202313058493);湖南省教育厅青年项目(22B0379);长沙市自然科学基金(kq2208192)。

摘　　要：补阳还五汤(Buyang Huanwu Decoction,BHD)具有补气活血通络之功效和抗血栓、抗神经损伤、抑制细胞凋亡等药理作用,临床上常用于治疗缺血性脑卒中。通过对BHD的化学成分、药理作用进行系统总结与梳理,依照质量标志物(quality marker,Q-Marker)理念,从传递与溯源、特有、有效、复方配伍、可测和超分子“印迹性”6个方面对BHD的QMarker进行预测分析,提示黄芪甲苷、黄芪皂苷I、毛蕊异黄酮葡萄糖苷、毛蕊异黄酮、芒柄花素、芒柄花苷、阿魏酸、川芎嗪、藁本内酯、芍药苷、苦杏仁苷、羟基红花黄色素A可作为该复方的Q-Marker,后续可选择这些Q-Marker为指标,根据药材、饮片、制剂的量值传递规律建立并控制BHD全过程质量可溯源体系。Buyang Huanwu Decoction(补阳还五汤,BHD)has the effects of tonifying qi,activating blood and dredging collaterals,as well as antithrombotic,anti-nerve damage,inhibiting apoptosis and other pharmacological effects.It is commonly used in clinical treatment of ischemic stroke.This paper systematically summarizes and sorts out the research progress of the chemical constituents and pharmacological effects of BHD.On this basis,according to the concept of quality marker(Q-Marker),the Q-Marker of BHD was predicted and analyzed from six aspects:transmission and traceability,specificity,effectiveness,compound compatibility,testability,and supramolecular“imprinting”.The Q-Marker of BHD was predicted and analyzed,suggesting that astragaloside Ⅳ,astragaloside Ⅰ,calycosin7-O-β-D-glucopyranoside,calycosin,formononetin,ononin,ferulic acid,ligustrazine,ligustilide,paeoniflorin,amygdalin,hydroxysafflor yellow A can be used as the Q-Marker of the formula,and these Q-Markers can be selected as indicators in the future,and the quality traceability system of BHD in the whole process can be established and controlled according to the quantity transfer law of medicinal materials,decoction pieces and preparations.

关 键 词：补阳还五汤 质量标志物 质量控制 黄芪甲苷 毛蕊异黄酮 芒柄花素 芒柄花苷 阿魏酸 川芎嗪 藁本内酯 芍药苷 苦杏仁苷 

分 类 号：R285[医药卫生—中药学]