中药通过免疫调节抗外阴阴道念珠菌病研究进展  

Research progress on traditional Chinese medicine against vulvovaginal candidiasis through immune regulation

作　　者：吴惠 吴大强[1,2] 邵菁 汪天明[1,2] 汪长中 WU Hui;WU Daqiang;SHAO Jing;WANG Tianming;WANG Changzhong(School of Integrated Traditional and Western Medicine,Anhui University of Chinese Medicine,Hefei 230012,China;Institute of Integrated Traditional Chinese and Western Medicine,Anhui Academy of Chinese Medicine,Hefei 230012,China)

机构地区：[1]安徽中医药大学中西医结合学院,安徽合肥230012 [2]安徽省中医药科学院,中西医结合研究所,安徽合肥230012

出　　处：《中草药》2024年第13期4588-4597,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82374173);安徽省重点研发资助项目(202104a07020020);安徽省高校自然科研重点项目(KJ2021A0590)。

摘　　要：外阴阴道念珠菌病(vulvovaginal candidiasis,VVC)发生率近年来呈上升趋势,氟康唑等一线抗真菌药物因长期使用导致菌株耐药现象日益严重。中药治疗VVC具有低不良反应和低复发率、不易耐药等优势,其对于VVC的治疗除了一定程度直接作用于菌体外,主要通过调节机体免疫功能发挥效应。通过对近年来中药从免疫调节角度对VVC作用机制的最新研究进展进行综述,为中药干预VVC提供新的思路或借鉴。The incidence of vulvovaginal candidiasis(VVC)has been on the rise in recent years.The resistance of strains to first-line antifungal drugs such as fluconazole has become increasingly severe due to long-term use.The treatment of VVC with traditional Chinese medicine(TCM)has the advantages of low adverse effect,low recurrence rate and low drug resistance.In addition to its direct effect on the fungus,the treatment of VVC exerts its effect mainly through the regulation of the immune function of the organism.By reviewing the latest research progress on the mechanism of TCM’s action on VVC from the perspective of immunomodulation in recent years,we can provide new ideas or reference for TCM intervention of VVC.

关 键 词：外阴阴道念珠菌病 免疫调节 固有免疫 适应性免疫 苦参 蛇床子 姜黄素 

分 类 号：R285[医药卫生—中药学]