柚皮素治疗消化系统疾病的药理作用及机制研究进展  

Advances in studies on pharmacological effects and mechanisms of naringenin in treatment of digestive system diseases

作　　者：陈孟瑶 乐音子[1] 颜帅[1] CHEN Mengyao;YUE Yinzi;YAN Shuai(Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,China)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215009

出　　处：《中草药》2024年第13期4622-4632,共11页Chinese Traditional and Herbal Drugs

基　　金：姑苏卫生人才项目(GSWS2020085);苏州市第三十二批科技发展计划(医疗卫生科技创新-应用基础研究)项目(SKJY2021136);江苏省卫生健康委科研项目(M2022104);苏州市医疗卫生科技创新项目(SKJY2021133)。

摘　　要：柚皮素是一种广泛存在于柑橘类水果及药用植物中的天然黄酮类化合物,可通过调节肠道功能障碍、抗炎、抗氧化、抗纤维化、抗肿瘤、调节脂质代谢等多种药理活性对消化系统产生保护作用,有望成为治疗消化系统疾病的候选药物,具有广阔的开发应用前景。对近5年国内外相关文献进行查阅、比较与分析,通过归纳与整理,综述柚皮素治疗消化系统疾病的药理作用及机制研究进展,以期为其新用途开发提供参考。Naringenin is a kind of natural flavonoid widely existing in citrus fruits and medicinal plants.It can protect the digestive system from diseases by controlling intestinal dysfunction,anti-inflammation,anti-oxidation,antifibrosis,antitumor,and lipid metabolism and other pharmacological effects.It is predicted to become a candidate medicine for the treatment of digestive system illnesses,with significant development and application potential.This paper reviewed,compared,and assessed pertinent domestic and international literature published during the previous five years.In order to provide a reference for the development of new applications,the pharmacological effects and mechanisms of naringenin in the treatment of diseases of the digestive system were reviewed through induction and collation.

关 键 词：柚皮素 消化系统疾病 调节肠道功能障碍 抗炎 抗氧化 抗纤维化 抗肿瘤 调节脂质代谢 

分 类 号：R285[医药卫生—中药学]