基于数据挖掘探讨中药复方治疗气阴两虚型2型糖尿病的用药规律  

Medication rule analysis of traditional Chinese medicine compound in treatment of type 2 diabetes mellitus with qi and yin deficiencies based on data mining

作　　者：吴挺超 何茗苠 冯皓月 岳仁宋[2] 吴绍祺 温川飙[3] WU Tingchao;HE Mingmin;FENG Haoyue;YUE Rensong;WU Shaoqi;WEN Chuanbiao(Chengdu Second People’s Hospital,Chengdu 610011,China;Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都市第二人民医院,四川成都610011 [2]成都中医药大学附属医院,四川成都610072 [3]成都中医药大学,四川成都610075

出　　处：《中草药》2024年第14期4811-4823,共13页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82174236)。

摘　　要：目的挖掘中药复方治疗气阴两虚型2型糖尿病(type 2 diabetes mellitus,T2DM)的用药规律。方法从中国知网、维普中文平台、中国生物医学文献系统、万方知识平台和PubMed数据库检索相关的临床研究,建立数据库,通过SPSS Statistics和SPSS Modeler软件对复方进行药物剂型、频数、药性、药味、归经、剂量、关联规则和系统聚类等分析,深入挖掘处方用药规律。结果共有241首复方,175味中药纳入数据库中。黄芪、生地黄和山药是气阴两虚型T2DM治疗复方使用频率最高的单药。黄芪、山药和丹参在所有复方中的整体应用剂量偏大,而五味子、黄连和甘草的应用剂量偏小。丹参是夹瘀兼证中最常应用的活血化瘀药,黄连和知母是夹热兼证最常应用的清热药,黄连和苍术是夹痰/夹湿兼证应用最高频的除湿药。复方中药的药性以寒性和平性为主,药味以甘味和苦味为主,药物归经以肺经、脾经和肾经居多。气阴两虚型T2DM治疗复方中潜在支持度最高的对药及角药分别是“黄芪-生地黄”和“黄芪-生地黄-山药”。高频药物聚类分析显示存在5个潜在的核心处方。结论数据挖掘较为全面地揭示了气阴两虚型T2DM治疗复方的用药规律,为气阴两虚型T2DM的临床和科研工作提供了思路借鉴。Objective To explore the medication rules of traditional Chinese medicine(TCM) formulas in treating type 2 diabetes mellitus(T2DM) with qi and yin deficiencies.Method Relevant clinical researches were retrieved from CNKI,VIP,SinoMed,Wanfang,and Pubmed databases.A database was established,and SPSS Statistics and SPSS Modeler softwares were adopted to analyze the herb dosage form,single-herb frequency,herb property,herb flavor,meridian tropism,dose,hierarchical clustering,and association rule,so as to deeply explore the medication rules of compound prescriptions.Results A total of 241 compound prescriptions and 175 herbs were included in the data mining.Huangqi(Astragali Radix),Shengdihuang(Rehmanniae Radix),and Shanyao(Dioscoreae Rhizoma) were the most frequently used single-herbs in the treatment of T2DM with qi and yin deficiencies.The overall dosages of Astragali Radix,Dioscoreae Rhizoma,and Danshen(Salviae Miltiorrhizae Radix et Rhizoma) in all compound prescriptions were relatively large,while the dosages of Wuweizi(Schisandrae Chinensis Fructus),Huanglian(Coptidis Rhizoma),and Gancao(Glycyrrhizae Radix et Rhizoma) were small.Salviae Miltiorrhizae Radix et Rhizoma was the most commonly used herb for invigorating blood and removing stasis in blood-stasis accompanied syndrome;Coptidis Rhizoma and Zhimu(Anemarrhenae Rhizoma) were the most commonly used herbs for clearing heat in heat accompanied syndrome;Coptidis Rhizoma and Cangzhu(Atractylodis Rhizoma) were the most commonly used herbs for removing dampness in phlegm or dampness accompanied syndrome.Cold and neutral are the high-frequency herb properties of the compound prescriptions;Sweet and bitter are the high-frequency herb flavors;Lung meridian,spleen meridian,and kidney meridian are the high-frequency herb meridian tropisms.The couplet and triangular herbs with the highest support degree are “Astragali Radix-Rehmanniae Radix” and “Astragali Radix-Rehmanniae Radix-Dioscoreae Rhizoma”,respectively.Five potential core prescriptions were existed by c

关 键 词：2型糖尿病 气阴两虚证 数据挖掘 黄芪 生地黄 山药 丹参 黄连 知母 苍术 

分 类 号：R289[医药卫生—方剂学] R283.21[医药卫生—中药学]