聚乙炔类成分纯化技术及其在人参属中的研究进展  

Purification technologies of polyacetylene components and their research progress in Panax plants

作　　者：徐蓓 王洪达 洪莉丽 邹雅丹 杨文志 XU Bei;WANG Hongda;HONG Lili;ZOU Yadan;YANG Wenzhi(National Key Laboratory of Chinese Medicine Modernization,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学现代中药创制全国重点实验室,天津301617

出　　处：《中草药》2024年第14期4962-4977,共16页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82374030);组分中药国家重点实验室资助课题(CBCM2023202);天津市杰出青年基金(23JCJQJC00030)。

摘　　要：聚乙炔是一类弱极性化合物,分布于人参、柴胡和党参等中药中,具有多种药理活性,近年来在中药学或天然产物研究领域得到了广泛关注。通过系统检索PubMed、Web of Science、ScienceDirect、Willy及中国知网等数据库中聚乙炔相关文献,聚焦当前研究现状及热点方向,总结了不同植物中聚乙炔类化合物分离纯化的主要技术手段,概括了聚乙炔类化合物在人参属植物中的植化分离、药理活性及含量测定相关的研究进展,为中药中聚乙炔类化合物的富集、分离与活性评价等提供参考。Polyacetylenes are a kind of low-polarity compounds,distributed in some traditional Chinese medicines(TCMs),such as Renshen(Ginseng Radix et Rhizoma),Chaihu(Bupleuri Radix)and Dangshen(Codonopsis Radix)etc.They have exhibited a wide spectrum of pharmacological activities,and received extensive concern in the field of TCMs or natural products research in recent years.A systematic searching of the literature related to polyacetylenes was performed in the databases such as PubMed,Web of Science,ScienceDirect,Willy,China National Knowledge Infrastructure,and the others,by focusing on the current research status and the hot spots,the main technical means of separation and purification of the polyacetylene compounds from different plants,and the research progress of phytochemical separation,pharmacological activity and quantitative assays of polyacetylene compounds in the Panax plants were summarized.It can provide reference for the enrichment,separation,and activity evaluation of polyacetylene compounds in TCMs.

关 键 词：聚乙炔 人参属 分离技术 含量测定 活性评价 人参炔醇 人参环氧炔醇 

分 类 号：R28[医药卫生—中药学]