基于群体感应和免疫逃逸的铜绿假单胞菌耐药机制及中药干预策略研究进展  

Research progress on antibiotic-resistance mechanisms of Pseudomonas aeruginosa-induced infection based on quorum-sensing and immune escape and intervention strategies of traditional Chinese medicine

作　　者：吴娅丽 李伟霞[1,2,3] 王晓艳 陈小菲[1,2] 张明亮 张辉[1,2] 杨柳青 唐进法 WU Yali;LI Weixia;WANG Xiaoyan;CHEN Xiaofei;ZHANG Mingliang;ZHANG Hui;YANG Liuqing;TANG Jinfa(Department of Pharmacy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003,China;Henan Engineering Research Center of Clinical Application,Evaluation and Transformation of Traditional Chinese Medicine,Henan Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine,Henan Engineering Research Center of Safety Evaluation and Risk Management of Traditional Chinese Medicine,Zhengzhou 450003,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一附属医院药学部,河南郑州450003 [2]河南省中药临床应用、评价与转化工程研究中心,河南省中药临床药学中医药重点实验室,河南省中药安全评价与风险防控工程研究中心,河南郑州450003 [3]河南中医药大学药学院,河南郑州450046

出　　处：《中草药》2024年第14期4991-5001,共11页Chinese Traditional and Herbal Drugs

基　　金：河南省科技研发计划联合基金(优势学科培育类)项目(232301420083);河南省中医药科学研究专项(2023ZXZX1026);河南省高等学校重点科研项目(23A360008);河南中医药大学第一附属医院博士科研启动基金项目(2021BSJJ008);河南省高校科技创新团队(23IRTSTHN026)。

摘　　要：铜绿假单胞菌(Pseudomonas aeruginosa,PA)是公认的引起医院内感染的主要病原菌之一,以抗生素耐药著称,其耐药机制主要与群体感应和免疫逃逸相关。中医药能从多方面治疗耐药PA所致感染。通过基于群体感应和免疫逃逸关联耐药机制,对PA的流行病学及危险因素、耐药机制、中医药干预策略等方面进行系统综述,为临床中药及中西药合用治疗耐药PA感染提供依据,并为中药-机体、中药-病原菌及中药-抗生素间相互作用的进一步研究提供方向。Pseudomonas aeruginosa(PA) is recognized as one of the main pathogens of nosocomial infection and is famous for antibiotic resistance,and its resistance mechanism is mainly related to quorum-sensing and immune escape.In traditional Chinese medicine(TCM),PA-induced infection could be intervened from multiple pathways.In this paper,the epidemiology,risk factors and resistance mechanisms of PA,and intervention mechanism of TCM were systematically reviewed based on quorum-sensing and immune escape,with view to providing a basis for the clinical application of TCM and the synergistic administration of TCM and antibiotics in the treatment of drug-resistant PA-infection,and providing the direction for the further study of the interactions between TCM-organism,TCM-pathogen interaction and TCM-antibiotics.

关 键 词：铜绿假单胞菌 耐药机制 中药 群体感应 免疫逃逸 

分 类 号：R285[医药卫生—中药学]